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タイトル
  • en Development of the 12-item questionnaire for quantitative assessment of depressive mixed state (DMX-12)
作成者
    • en Shinzato, Hotaka
    • ja 新里, 輔鷹
アクセス権 open access
権利情報
  • ja © 2019 Shinzato et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms. php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License
  • http://creativecommons.org/licenses/by-nc/3.0/
  • en http://creativecommons.org/licenses/by-nc/3.0/
主題
  • Other en major depressive episode
  • Other en depressive mixed state
  • Other en spontaneous instability
  • Other en vulnerable responsiveness
  • Other en disruptive emotion/behavior
内容注記
  • Other Background: Conventional categorical criteria have limitations in assessing the prevalence and severity of depressive mixed state (DMX). Thus, we have developed a new scale for screening and quantification of DMX and examined the symptomatological structure and severity of DMX in individuals with major depressive episode (MDE). Methods: Subjects were 154 patients with MDE (57 males and 97 females; age 13–83 years). Our original Japanese version of the self-administered 12-item questionnaire to assess DMX (DMX-12), together with the Quick Inventory of Depressive Symptomatology Self- Report Japanese version (QIDS-SR-J) and global assessment of functioning, were administered to each participant. The symptomatological structure of the DMX-12 was examined by exploratory factor analysis. Multiple regression analyses were used to analyze factors contributing to the DMX-12 scale. The relationships of this scale with categorical diagnoses (mixed depression by Benazzi and mixed features by DSM-5) were also investigated. Results: A three-factor model of the DMX-12 was extracted from exploratory factor analysis, namely, “spontaneous instability”, “vulnerable responsiveness”, and “disruptive emotion/behavior”. Multiple regression analyses revealed that age was negatively correlated with total DMX-12 score, while bipolarity and the QIDS-SR-J score were positively correlated. A higher score on the disruptive emotion/behavior subscale was observed in patients with mixed depression and mixed features. Conclusion: The DMX-12 seems to be useful for screening DMX in conjunction with conventional categorical diagnoses. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX. The disruptive emotion/behavior subscale of the DMX-12 may be the most helpful in distinguishing patients with DMX from non-mixed patients.
  • Other 学位論文
出版者 en University of the Ryukyus
日付
    Issued2019-07-15
言語
  • eng
資源タイプ doctoral thesis
出版タイプ VoR
資源識別子 HDL http://hdl.handle.net/20.500.12000/46666 , HDL http://hdl.handle.net/20.500.12000/46666 , URI https://u-ryukyu.repo.nii.ac.jp/records/2012585
関連
  • DOI https://doi.org/10.2147/NDT.S215478
  • DOI https://doi.org/10.2147/NDT.S215478
収録誌情報
    • ISSN 1176-6328
    • ISSN 1178-2021
      • en Neuropsychiatric Disease and Treatment
      • 巻15 開始ページ1983 終了ページ1991
学位情報
  • 学位授与番号 甲第499号
  • 学位授与機関
    • 識別子名 kakenhi
    • 識別子 18001
    • 機関名称 ja 琉球大学
  • 学位授与年月日 2020-02-26
  • 学位名 ja 博士(医学)
ファイル
コンテンツ更新日時 2023-06-26