Is Preoperative Magnetic Resonance Imaging in a Daily Clinical Setting Useful to Evaluate Tumor Invasion Beyond the Pseudocapsule in Renal Cell Carcinoma?

Iwamoto Hideo; Nosaka Kanae; Miyoshi Hidenao; Makishima Karen; Ochiai Ryouya; Shimizu Ryutarou; Yumioka Tetsuya; Morizane Shuichi; Honda Masashi; Takenaka Atsushi

タイトル	en Is Preoperative Magnetic Resonance Imaging in a Daily Clinical Setting Useful to Evaluate Tumor Invasion Beyond the Pseudocapsule in Renal Cell Carcinoma?
作成者	en Iwamoto, Hideo en Nosaka, Kanae en Miyoshi, Hidenao en Makishima, Karen en Ochiai, Ryouya en Shimizu, Ryutarou en Yumioka, Tetsuya en Morizane, Shuichi en Honda, Masashi en Takenaka, Atsushi
権利情報	(C) 2021 Tottori University Medical Press.
内容注記	Other Background: We wanted to clarify whether preoperative magnetic resonance imaging (MRI) in the clinical setting can evaluate the pathologic pseudocapsule (PC) morphology with high accuracy in renal cell carcinoma (RCC). Methods: We retrospectively analyzed 34 consecutive patients who underwent MRI (1.5 or 3.0T, 5 mm slices) prior to partial nephrectomy (PN) for RCC at our institution between January 2010 and December 2019. First, the correlation between PC morphology (complete or incomplete) and tumor infiltration to the renal parenchyma was examined as pathologic validation. Second, the concordance rate of PC morphology between pathologic tissue and preoperative MRI was evaluated as radiologic validation. Third, risk factor for renal parenchymal invasion in RCC was analyzed. Results: In the pathologic validation, parenchymal invasion rates were 11% and 28% in the “complete PC” and “incomplete PC” groups, respectively. In the radiologic validation, pathological PC morphology could be diagnosed on preoperative MRI in 17 patients (50.0%). “None PC” on MRI had the lowest positive predictive value (PPV) (0%), “partial PC” on MRI had a good PPV (76.5%), “complete PC” on MRI had a relatively low PPV (33.3%). Unfortunately, these data were insufficient for diagnostic accuracy. As risk factor for renal parenchymal invasion in RCC, only pathologic subtype (non-clear cell) was found to have significant differences in the multivariate analysis. Conclusion: The results of this study suggest that renal tumors with pathologically incomplete PC have a high possibility of renal parenchymal invasion. However, it is currently difficult to accurately evaluate pathologic PC morphology by preoperative MRI in the clinical setting.
出版者	Tottori University Medical Press
日付	Issued2021-11-29
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	URI https://repository.lib.tottori-u.ac.jp/records/4707
関連	isIdenticalTo DOI https://doi.org/10.33160/yam.2021.11.004 Iwamoto H, Nosaka K, Miyoshi H, et al. Is Preoperative Magnetic Resonance Imaging in a Daily Clinical Setting Useful to Evaluate Tumor Invasion Beyond the Pseudocapsule in Renal Cell Carcinoma?. Yonago Acta Medica. 2021, 64(4), 345-352. doi:10.33160/yam.2 URI http://www.lib.tottori-u.ac.jp/yam/yam/yam64-4/64-4contents.html http://www.lib.tottori-u.ac.jp/yam/yam/yam64-4/64-4contents.html DOI https://doi.org/10.33160/yam.2021.11.004 https://doi.org/10.33160/yam.2021.11.004
収録誌情報	NCID AA00892882 ISSN 05135710 Yonago Acta Medica en Yonago Acta Medica 巻64 号4 開始ページ345 終了ページ352
ファイル	yam64(4)_345.pdf 1.5 MB (application/pdf) Available2023-03-15
コンテンツ更新日時	2023-10-03