| タイトル |
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en
Targeting Neurogenesis in Seeking Novel Treatments for Ischemic Stroke
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| 作成者 |
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| 権利情報 |
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| 主題 |
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Other
neurogenesis
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Other
ischemic stroke
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Other
cell therapy
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Other
rehabilitations
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| 内容注記 |
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Other
The interruption of cerebral blood flow leads to ischemic cell death and results in ischemic stroke. Although ischemic stroke is one of the most important causes of long-term disability and mortality, limited treatments are available for functional recovery. Therefore, extensive research has been conducted to identify novel treatments. Neurogenesis is regarded as a fundamental mechanism of neural plasticity. Therefore, therapeutic strategies targeting neurogenesis are thought to be promising. Basic research has found that therapeutic intervention including cell therapy, rehabilitation, and pharmacotherapy increased neurogenesis and was accompanied by functional recovery after ischemic stroke. In this review, we consolidated the current knowledge of the relationship between neurogenesis and treatment for ischemic stroke. It revealed that many treatments for ischemic stroke, including clinical and preclinical ones, have enhanced brain repair and functional recovery post-stroke along with neurogenesis. However, the intricate mechanisms of neurogenesis and its impact on stroke recovery remain areas of extensive research, with numerous factors and pathways involved. Understanding neurogenesis will lead to more effective stroke treatments, benefiting not only stroke patients but also those with other neurological disorders. Further research is essential to bridge the gap between preclinical discoveries and clinical implementation.
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| 出版者 |
en
MDPI
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
URI
https://ousar.lib.okayama-u.ac.jp/66023
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| 関連 |
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isIdenticalTo
PMID
37893146
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isIdenticalTo
DOI
https://doi.org/10.3390/biomedicines11102773
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| 収録誌情報 |
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Biomedicines
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巻11
号10
開始ページ2773
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| ファイル |
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| コンテンツ更新日時 |
2024-01-26 |
