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タイトル
  • Extended ensemble simulations of a SARS-CoV-2 nsp1–5’-UTR complex
作成者
    • Sakuraba, Shun
    • Xie, Qilin
    • Kasahara, Kota
    • Iwakiri, Junichi
    • Kono, Hidetoshi
    • en Shun, Sakuraba
    • en Hidetoshi, Kono
アクセス権 metadata only access
内容注記
  • Abstract Non-structural protein 1 (nsp1) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a 180-residue protein which blocks the translation of SARS-CoV-2 infected cells. Although it has been known that SARS-CoV-2's own RNA evades nsp1's host translation shutoff, its molecular mechanism has been poorly understood. We performed an extended ensemble molecular dynamics simulation to investigate the mechanism of the viral RNA evasion. Simulation results showed that the stem loop structure of SARS-CoV-2 RNA 5'-untranslated region is recognized by both nsp1's globular region and intrinsically disordered region.
出版者 PLoS
日付
    Issued2022-02
言語
  • eng
資源タイプ journal article
資源識別子 URI https://repo.qst.go.jp/records/84902
関連
  • DOI https://doi.org/10.1371/journal.pcbi.1009804
  • URI https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1009804
収録誌情報
    • ISSN 1553-7358
      • PLoS Computational Biology
      • 巻18 号1 開始ページe1009804
コンテンツ更新日時 2023-07-10