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タイトル
  • Retrovirus Entry by Endocytosis and Cathepsin Proteases
作成者
権利情報
  • © 2012 Yoshinao Kubo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
内容注記
  • Other Retroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells. Understanding the entry mechanism of retroviruses contributes to developments of novel therapeutic approaches against retrovirus-induced diseases and efficient exploitation of retroviral vectors. Entry of enveloped viruses into host cell cytoplasm is achieved by fusion between the viral envelope and host cell membranes at either the cell surface or intracellular vesicles. Many animal retroviruses enter host cells through endosomes and require endosome acidification. Ecotropic murine leukemia virus entry requires cathepsin proteases activated by the endosome acidification. CD4-dependent human immunodeficiency virus (HIV) infection is thought to occur via endosomes, but endosome acidification is not necessary for the entry whereas entry of CD4-independent HIVs, which are thought to be prototypes of CD4-dependent viruses, is low pH dependent. There are several controversial results on the retroviral entry pathways. Because endocytosis and endosome acidification are complicatedly controlled by cellular mechanisms, the retrovirus entry pathways may be different in different cell lines.
  • Other identifier:Advances in Virology, 2012, pp.1-14; 2012
  • Other identifier:16878647
出版者 Hindawi Publishing Corporation
日付
    Issued2012
言語
  • eng
資源識別のタイプ journal article
出版タイプ VoR
資源識別子 URI http://hdl.handle.net/10069/31562
関連
  • isIdenticalTo DOI https://doi.org/10.1155/2012/640894
収録誌情報
    • ISSN 1687-8639
      • Advances in Virology 2012, 1-14
ファイル
コンテンツ更新日時 2013-04-30