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CXCR4-Tropic, But Not CCR5-Tropic, Human Immunodeficiency Virus Infection Is Inhibited by the Lipid Raft-Associated Factors, Acyclic Retinoid Analogs, and Cholera Toxin B Subunit
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作成者 |
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権利情報 |
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This is a copy of an article published in the AIDS Research and Human Retroviruses © 2013 Mary Ann Liebert, Inc.; AIDS Research and Human Retroviruses is available online at: http://online.liebertpub.com.
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主題 |
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chemokine receptor CCR5
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chemokine receptor CXCR4
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cholera toxin B subunit
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geranylgeranoic acid
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peretinoin
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retinoid derivative
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transactivator protein
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unclassified drug
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virus envelope protein
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virus vector
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antiviral therapy
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article
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cell viability
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controlled study
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human
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human cell
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Human immunodeficiency virus 1 infection
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lipid raft
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membrane fusion
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nonhuman
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priority journal
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protein depletion
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protein expression
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target cell
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viral tropism
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virus particle
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virus strain
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内容注記 |
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Development of an effective low-cost anti-acquired immunodeficiency syndrome (AIDS) drugs is needed for treatment of AIDS patients in developing countries. Host cell lipid raft microdomains, which are enriched with cholesterol, glycolipids, ceramide, and gangliosides, are important for human immunodeficiency virus type 1 (HIV-1) entry. Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1. In this study, we found that the acyclic retinoid analogs geranylgeranoic acid (GGA) and NIK-333 as well as CT-B efficiently attenuate CXCR4-tropic, but not CCR5-tropic, HIV-1 vector infection. We also found that GGA and NIK-333 suppress CXCR4-tropic HIV-1 infection by attenuating CXCR4 expression. CT-B also attenuated CXCR4-tropic HIV-1 infection, but did not suppress CXCR4 expression. These results suggest a distinct role for lipid raft microdomains in CXCR4- and CCR5-tropic HIV-1 infections and illuminate novel agents for the development of AIDS therapy.
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identifier:AIDS Research and Human Retroviruses, 29(2), pp.279-288; 2013
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identifier:19318405
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出版者 |
Mary Ann Liebert Inc.
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日付 |
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言語 |
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資源識別のタイプ |
journal article |
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VoR |
資源識別子 |
URI
http://hdl.handle.net/10069/31581
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関連 |
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DOI
https://doi.org/10.1089/aid.2012.0174
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収録誌情報 |
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AIDS Research and Human Retroviruses
29(2), 279-288
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ファイル |
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コンテンツ更新日時 |
2013-05-01 |