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タイトル
  • Serum Starvation Activates NF-κB Through G Protein β2 Subunit-Mediated Signal
作成者
権利情報
  • This is a copy of an article published in the DNA and Cell Biology © 2012 Mary Ann Liebert, Inc.; DNA and Cell Biology is available online at: http://online.liebertpub.com.
内容注記
  • Other Several cell stresses induce nuclear factor-kappaB (NF-κB) activation, which include irradiation, oxidation, and UV. Interestingly, serum-starving stress-induced NF-κB activation in COS cells, but not in COS-A717 cells. COSA717 is a mutant cell line of COS cells that is defective of the NF-κB signaling pathway. We isolated genes with compensating activity for the NF-κB pathway and one gene encoded the G protein b2 (Gb2). Gb2 is one of the G rotein-coupled receptor signaling effectors. In COS-A717 cells, Gb2 expression is significantly reduced. In Gb2 cDNA-transfected COS-A717 cells, the NF-κB activity was increased along with the recovery of Gb2 expression. Furthermore, serum-starving stress induced the NF-κB activity in Gb2-transfected COS-A717 cells. Consistently, the serum-starved COS cells with siRNA-reduced Gb2 protein expression showed decreased NF-κB activity. These results indicate that Gb2 is required for starvation-induced NF-κB activation and constitutive NF-kB activity. We propose that serum contains some molecule(s) that strongly inhibits NF-κB activation mediated through Gβ2 signaling.
  • Other identifier:DNA and Cell Biology, 31(11), pp.1636-1644; 2012
  • Other identifier:15577430
出版者 Mary Ann Liebert Inc.
日付
    Issued2012-11-01
言語
  • eng
資源識別のタイプ journal article
出版タイプ VoR
資源識別子 URI http://hdl.handle.net/10069/32434
関連
  • isIdenticalTo DOI https://doi.org/10.1089/dna.2012.1666
収録誌情報
    • ISSN 1044-5498
      • DNA and Cell Biology 31(11), 1636-1644
ファイル
コンテンツ更新日時 2013-06-24