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タイトル
  • en Diagnostic yield and the number of tumor cells of ultrathin bronchoscopy for peripheral lung lesions: A comparison with thin bronchoscopy
作成者
    • en Yatani, Atsuhiko
    • en Katsurada, Naoko ja 桂田, 直子 ja-Kana カツラダ, ナオコ
    • NRID 1000030816195
    • en Fukui, Takafumi
    • en Yamada, Jun
    • en Satoh, Hiroki
    • en Mimura, Chihiro
    • en Hazama, Daisuke ja 羽間, 大祐 ja-Kana ハザマ, ダイスケ
    • NRID 1000030894604
    • en Yamamoto, Masatsugu ja 山本, 正嗣 ja-Kana ヤマモト, マサツグ
    • NRID 1000040542139
    • en Tanaka, Tomonori ja 田中, 伴典 ja-Kana タナカ, トモノリ
    • NRID 1000070624394
    • en Tachihara, Motoko ja 立原, 素子 ja-Kana タチハラ, モトコ
    • NRID 1000040448626
アクセス権 open access
権利情報
  • en © 2023 Yatani et al.
  • https://creativecommons.org/licenses/by/4.0/deed.en
  • en This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
内容注記
  • Abstract en Ultrathin bronchoscopy has been reported to have a higher diagnostic yield than thin bronchoscopy for small peripheral lung lesions in transbronchial biopsy under radial endobronchial ultrasonography (EBUS). However, data comparing the number of tumor cells in non-small cell lung cancer (NSCLC) are limited. We retrospectively compared the number of NSCLC tumor cells in peripheral lung lesions obtained using an ultrathin bronchoscope and a thin bronchoscope with radial EBUS between April 2020 and October 2021. In all patients, we used virtual bronchoscopic navigation (VBN) software, and guide sheaths were used in thin bronchoscopy cases. A total of 175 patients were enrolled in this study. Ultrathin bronchoscopy cases (n = 69) had lesions with a smaller diameter that are more peripherally located compared to thin bronchoscopy cases (n = 106) (median, 25.0 vs. 26.5 mm, mean bronchial generations accessed by bronchoscopy; 4.4±1.2 vs. 3.8±1.0, respectively; p<0.010). There were no significant differences in the overall diagnostic yield (ultrathin vs. thin bronchoscopy cases, 68.1% vs. 72.6%, p = 0.610) or diagnostic yield in only lung cancer cases (78.6% vs. 78.5%, p = 1.000). In histologically NSCLC cases (n = 102), the maximum number of tumor cells per slide as the primary endpoint was similar (average, 307.6±246.7 vs. 328.7±314.9, p = 0.710). The success rate of the Oncomine™ analysis did not differ significantly (80.0% vs. 55.6%, p = 0.247). The yield of NSCLC tumor cells was not different between the samples obtained by the ultrathin bronchoscope and those obtained by the thin bronchoscope.
出版者 en Public Library of Science
日付
    Issued2023-08-24 , Available2023-10-18
言語
  • eng
資源タイプ journal article
出版タイプ VoR
資源識別子 HDL https://hdl.handle.net/20.500.14094/0100483378
関連
  • isIdenticalTo DOI https://doi.org/10.1371/journal.pone.0290609
収録誌情報
    • EISSN 1932-6203
      • en PLoS ONE
      • 巻18 号8 開始ページe0290609
ファイル
    • fulltext 0100483378.pdf
    • 1.21MB (application/pdf)
      • Available2023-10-18
コンテンツ更新日時 2023-10-23