小肝細胞癌の肉眼型分類からみた腫瘍特性 : 細胞増殖能とDoubling Timeの観点から

上野 真一; 迫田 雅彦; 飯野 聡; 蔵原 弘; 南 幸次; 安藤 慶; 又木 雄弘; 喜島 裕子; 前村 公成; 大脇 哲弘; 北薗 正樹; 石神 純也; 新地 洋之; 夏越 祥次

タイトル	ja 小肝細胞癌の肉眼型分類からみた腫瘍特性 : 細胞増殖能とDoubling Timeの観点から
その他のタイトル	Tumor cell proliferation and doubling time of small nodular hepatocellular carcinoma based on gross classification ショウカンサイボウガンノニクガンケイブンルイカラミタシュヨウトクセイ : サイボウゾウショクノウト Doubling Time ノカンテンカラ
作成者	上野, 真一 NRID 1000040322317 迫田, 雅彦 NRID 1000040418851 飯野, 聡蔵原, 弘 NRID 1000070464469 南, 幸次安藤, 慶又木, 雄弘 NRID 1000010444902 喜島, 裕子前村, 公成 NRID 1000030398292 大脇, 哲弘北薗, 正樹 NRID 1000030398276 石神, 純也 NRID 1000090325803 新地, 洋之 NRID 1000060284874 夏越, 祥次 NRID 1000070237577
主題	Other Hepatocellular carcinoma Other MIB-1 Other Doubling time Other Gross classification Other Anatomic resection NDC 494
内容注記	Other It is reported that gross classification of hepatocellular carcinoma (HCC) is associated with tumors’ malignant behavior.We studied the characteristics and differences between two types of gross classification of HCCs (i.e. Boundary type:single nodular HCC; Nonboundary type: single nodular with extranodular growth, confluent multinodular, and invasiveHCCs) by using MIB-1 labeling index (LI) and tumor volume doubling time (DT).　 The DT of 87 HCCs, less than 5 cm in diameter at the start of the observation period, was calculated based onultrasonographic images. The natural progression of the lesions were observed during 1 month or more.Regarding MIB-1 labeling index (LI) of the 87 lesions, we performed immunohistochemical staining (ABC method) withthe MIB-1 monoclonal antibody using paraffin-embedded sections obtained by liver resection. The incidence of micrometastasis in the resected sections and the postoperative recurrence ratio were clearly higher inthe nonboundary type (n=19) than in the boundary type (n=68). MIB-1 LI and DT were 12.1 +/- 1.3% (mean +/- SE) and274.8 +/- 36.2 days in the boundary type and 14.2 +/- 2.0% and 103.9 +/- 13.4 days in the nonboundary type. A significantdifference of DT was noticed between the 2 groups.　 These results showed that the nonboundary type HCCs included tumors with rapid growth more than those in theboundary type. Calculating DT would assist in distinguishing gross classification preinterventionally and in determiningsuitable therapy such as liver resection and ablation.
出版者	鹿児島大学
日付	Created2016-10-28
言語	jpn
資源タイプ	departmental bulletin paper
出版タイプ	VoR
資源識別子	URI http://hdl.handle.net/10232/14460
収録誌情報	NCID AN00040104 ISSN 0368-5063 鹿児島大学医学雑誌=Medical journal of Kagoshima University 巻63 号2 開始ページ31 終了ページ35
ファイル	https://ir.kagoshima-u.ac.jp/?action=repository_action_common_download&item_id=8093&item_no=1&attribute_id=16&file_no=1
コンテンツ更新日時	2023-07-18