| タイトル |
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en
Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
C-maf
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Other
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Cyclin D1
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Other
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Lens
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Other
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Immunohistochemistry
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NDC
496.1
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| 内容注記 |
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Abstract
en
The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf family genes have important roles in embryonic development and cellular differentiation. In this study, localization of cyclin D1, one of the cell cycle-related molecules, was examined immunohistochemically in developing lens cells of c-maf knockout (-/-) mice. At embryonic day 14 in wild-type mice, lens cells consisted of round epithelial cells in a single layer and regularly arranged elongated lens cells, indicating primary lens fiber cells. Cyclin D1-positive nuclei were observed in the lens epithelial cells, whereas cyclin D1 was not detected in the primary lens fiber cells. In c-maf -/- mice, a variety of round epithelial cells were located in the anterior and posterior lens. Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/5980
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| 関連 |
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URI
http://www.sciencedirect.com/science/journal/00651281
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isVersionOf
DOI
https://doi.org/10.1016/j.acthis.2005.10.002
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PMID
16325892
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| 収録誌情報 |
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en
Acta Histochemica
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巻107
号6
開始ページ469
終了ページ472
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
