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タイトル
  • en MSA-C is the predominant clinical phenotype of MSA in Japan : Analysis of 142 patients with probable MSA
作成者
    • en Soma, Hiroyuki
    • en Takei, Asako
    • en Fujiki, Naoto
    • en Yanagihara, Tetsuro
    • en Sasaki, Hidenao
アクセス権 open access
主題
  • Other en Multiple system atrophy
  • Other en Cerebellar ataxia
  • Other en Parkinsonism
  • Other en Autonomic failure
  • Other en MR imaging
  • Other en Diagnostic criteria
  • NDC 467
内容注記
  • Abstract en We investigated the clinical features and mode of disease progression in 142 patients with probable multiple system atrophy (MSA) according to the Consensus Criteria. The subjects included 84 men and 58 women with a mean age at onset of 58.2 ± 7.1 years (range: 38–79 years). Cerebellar signs were detected in 87.3% of these patients at the time of initial examination, and were found in 95.1% of them at latest follow-up. MSA-C was diagnosed in 83.8% of the patients at their first examination. Parkinsonism was initially detected in 28.9% of the patients, increasing to 51.4% at the latest follow-up. Among all of the subjects, only 16.2% were classified as having MSA-P on initial examination. At the latest follow-up, parkinsonian features had become predominant over cerebellar features in 24.6% of the 65 patients with MSA-C who were followed for more than 3 years. Although parkinsonism usually masked the signs of cerebellar involvement in MSA-C patients, none of the patients with MSA-P at an early stage showed predominance of cerebellar features at the latest follow-up. Parkinsonism is the predominant feature of MSA among Western patients, even at an early stage, but this study showed that cerebellar deficits are the main feature in Japanese patients. This difference of disease manifestations between ethnic groups suggests that genetic factors may influence the clinical phenotype of MSA.
出版者 en Elsevier
日付
    Issued2006-11-15
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/14449
関連
  • URI http://www.sciencedirect.com/science/journal/0022510X
  • isVersionOf DOI https://doi.org/10.1016/j.jns.2006.05.064
  • PMID 16828805
収録誌情報
    • PISSN 0022-510X
      • en Journal of the Neurological Sciences
      • 巻249 号2 開始ページ115 終了ページ121
ファイル
    • fulltext yabe_jns.pdf
    • 373.64 KB (application/pdf)
      • Issued2006-11-15
コンテンツ更新日時 2023-07-26