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タイトル
  • en Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitis
作成者
アクセス権 open access
主題
  • Other en Allergic conjunctivitis
  • Other en Atopic dermatitis
  • Other en Eye
  • Other en MIF
  • Other en Serum
  • Other en Tears
  • NDC 496.3
内容注記
  • Abstract en Background and aims of the study Atopic dermatitis is a chronic inflammatory skin disorder that often involves some ophthalmic features. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is associated with the generation of cell-mediated immune responses. Although serum MIF levels may be elevated in severe atopic dermatitis, the quantity of MIF in regional ocular fluid remains unknown. We measured MIF levels in tears (lacrimal fluid) of patients with atopic dermatitis. Patients and methods Tear samples were collected from 16 patients with atopic dermatitis, 10 patients with allergic conjunctivitis, and 15 healthy control subjects. The clinical severity of atopic dermatitis was evaluated according to the Scoring Atopic Dermatitis (SCORAD) index. The index was calculated by summing the following scores: extent criteria, intensity criteria, and subjective symptoms. Macrophage migration inhibitory factor levels were determined by a human MIF enzyme-linked immunosorbent assay. All comparisons were two-tailed, and P values <0.01 were considered as statistically significant. Results The mean MIF concentration in lacrimal fluid collected from healthy control subjects was 0.69±0.2 ng/ml. The mean tear MIF levels were 17.87±6.3 ng/ml in moderate-to-severe atopic dermatitis (SCORAD≥15, P=0.002), 0.93±0.08 ng/ml in mild atopic dermatitis (SCORAD<15), and 2.76±0.86 ng/ml in allergic conjunctivitis (P=0.008). Conclusions A proinflammatory cytokine MIF level was elevated in tears as well as serum in cases of severe atopic dermatitis. These results suggest that MIF may play an important role in the induction or enhancement of ophthalmic features related to severe atopic dermatitis.
出版者 en Springer
日付
    Issued2006-07
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/14627
関連
  • isVersionOf DOI https://doi.org/10.1007/s00417-005-0168-3
  • PMID 16331484
収録誌情報
    • PISSN 0721-832X
      • en Graefe's Archive for Clinical and Experimental Ophthalmology
      • 巻244 号7 開始ページ825 終了ページ828
ファイル
コンテンツ更新日時 2023-07-26