| タイトル |
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en
Expression of thymidine phosphorylase in choroidal malignant melanoma associated with neovascular glaucoma.
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
The definitive version is available at www.blackwell-synergy.com
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| 主題 |
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Other
en
choroid
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Other
en
dThdPase
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Other
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glaucoma
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Other
en
histopathology
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Other
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melanoma
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NDC
496.3
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| 内容注記 |
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Abstract
en
Reported herein is a case of 62-year-old man who complained of blurred vision and ocular pain in his right eye. The patient was diagnosed with choroidal melanoma complicated by neovascular glaucoma (NVG) and total retinal detachment, and he underwent enucleation of the eye. The isolated tumor was 2.5 × 2.5 cm in size. It was accompanied by intratumoral calcification, and consisted of epithelioid and spindle melanoma cells. There were a variety of microvessels in the stroma of the iris. The expression of thymidine phosphorylase (dThdPase), an angiogenic factor, was examined immunohistochemically. Cytoplasmic immunoreactivity for dThdPase was more prominent in the epithelioid cells than in spindle tumor cells. Another case of choroidal melanoma without NVG had less marked immunoreactivity. These results suggest that the production of dThdPase by melanoma cells correlates with the pathogenesis of NVG.
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| 出版者 |
en
Blackwell Publishing, Inc.
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/15822
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| 関連 |
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URI
http://www.blackwell-synergy.com
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isVersionOf
DOI
https://doi.org/10.1111/j.1440-1827.2005.01870.x
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PMID
16143032
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| 収録誌情報 |
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PISSN
1320-5463
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EISSN
1440-1827
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en
Pathology International
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巻55
号9
開始ページ569
終了ページ573
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
