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タイトル
  • en Quantitative analysis of biologic specimens by X-ray scanning analytic microscopy
作成者
アクセス権 open access
権利情報
  • en © 2004 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 70B: 146-151, 2004
主題
  • Other en X-ray scanning analytic microscopy (XSAM)
  • Other en quantitative analysis
  • Other en standard specimen
  • Other en dissolution
  • Other en implant
  • Other en elemental mapping
  • NDC 497
内容注記
  • Abstract en X-ray scanning analytic microscopy (XSAM) can be used to visualize the elemental distribution in biologic specimens. In this article, the authors prepared standard specimens for XSAM and performed quantitative analysis of various elements dissolved in soft tissues. Two different types of standard specimens were prepared. Methylmethacrylate (MMA) resin-based standard specimens were prepared with organic compounds of elements for low-concentration standards and lithium borate glass-based standard specimens were prepared with oxides of elements for higher concentration standards. Using these standard specimens, the P and Ca concentrations in normal rat tissue and dissolved Ni, Fe, and Ni concentrations around metal-implanted tissues were quantitatively analyzed. The estimated concentrations of dissolved Fe, Cu, and Ni from the implants were 1000, 40, and 20 mM, respectively. From the concentration levels causing inflammation around these implants, the high toxicity for soft tissue of Ni and Cu at low concentrations, for example, 10 mM, was confirmed. The toxicity of Cu was estimated as next to that of Ni. In contrast, Fe had low toxicity despite high concentrations of dissolved Fe of as much as 1000 mM. In this article, it was possible to estimate the nonmetallic elements and low-concentration metallic elements dispersed in soft tissue by XSAM.
出版者 en Wiley Periodicals, Inc.
日付
    Issued2004-07-15
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/16982
関連
  • URI http://www.interscience.wiley.com/
  • isVersionOf DOI https://doi.org/10.1002/jbm.b.30024
  • PMID 15199595
収録誌情報
    • PISSN 0021-9304
    • EISSN 1097-4636
      • en Journal of Biomedical Materials Research
      • 巻70 号1 開始ページ146 終了ページ151
ファイル
    • fulltext temp.pdf
    • 1.24 MB (application/pdf)
      • Issued2004-07-15
コンテンツ更新日時 2023-07-26