| タイトル |
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en
Infectivity-Enhancing Antibodies to Ebola Virus Glycoprotein
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
Copyright © 2001 American Society for Microbiology
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| 主題 |
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| 内容注記 |
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Abstract
en
Ebola virus causes severe hemorrhagic fever in primates, resulting in mortality rates of up to 100%, yet there are no satisfactory biologic explanations for this extreme virulence. Here we show that antisera produced by DNA immunization with a plasmid encoding the surface glycoprotein (GP) of the Zaire strain of Ebola virus enhances the infectivity of vesicular stomatitis virus pseudotyped with the GP. Substantially weaker enhancement was observed with antiserum to the GP of the Reston strain, which is much less pathogenic in humans than the Ebola Zaire and Sudan viruses. The enhancing activity was abolished by heat but was increased in the presence of complement system inhibitors, suggesting that heat-labile factors other than the complement system are required for this effect. We also generated an anti-Zaire GP monoclonal antibody that enhanced viral infectivity and another that neutralized it, indicating the presence of distinct epitopes for these properties. Our findings suggest that antibody-dependent enhancement of infectivity may account for the extreme virulence of the virus. They also raise issues about the development of Ebola virus vaccines and the use of passive prophylaxis or therapy with Ebola virus GP antibodies.
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| 出版者 |
en
American Society for Microbiology
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/28139
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| 関連 |
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isIdenticalTo
DOI
https://doi.org/10.1128/JVI.75.5.2324-2330.2001
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PMID
11160735
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| 収録誌情報 |
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en
Journal of Virology
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巻75
号5
開始ページ2324
終了ページ2330
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
