Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

Ito Toshihiro; Couceiro J. Nelson S. S.; Kelm Sørge; Baum Linda G.; Krauss Scott; Castrucci Maria R.; Donatelli Isabella; Kida Hiroshi; Paulson James C.; Webster Robert G.; Kawaoka Yoshihiro

タイトル	en Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
作成者	en Ito, Toshihiro en Couceiro, J. Nelson S. S. en Kelm, Sørge en Baum, Linda G. en Krauss, Scott en Castrucci, Maria R. en Donatelli, Isabella en Kida, Hiroshi NRID 1000010109506 en Paulson, James C. en Webster, Robert G. en Kawaoka, Yoshihiro NRID 1000070135838
アクセス権	open access
権利情報	en Copyright © 1998 American Society for Microbiology
主題	NDC 649
内容注記	Abstract en Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.
出版者	en American Society for Microbiology
日付	Issued1998-09
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/28141
関連	PMID 9696833
収録誌情報	PISSN 0022-538X en Journal of Virology 巻72 号9 開始ページ7367 終了ページ7373
ファイル	fulltext JV72-9.pdf 3.05 MB (application/pdf) Issued1998-09
コンテンツ更新日時	2023-07-26