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タイトル
  • en Early postnatal stress affects 5-HT1A receptor function in the medial prefrontal cortex in adult rats
作成者
    • en Matsuzaki, Hirokazu
    • en Matsumoto, Machiko
    • en Togashi, Hiroko
    • en Yamaguchi, Taku
    • en Yoshida, Takayuki
アクセス権 open access
主題
  • Other en 5-HT1A receptor
  • Other en Early postnatal stress
  • Other en Medial prefrontal cortex
  • NDC 491
内容注記
  • Abstract en Traumatic events in early life are associated with an increased risk of psychiatric diseases in adulthood. 5-hydroxytryptamine (5-HT)1A receptors are known to play a pivotal role in the 5-HTergic mechanisms associated with the etiology of stress-related disorders. The goal of the present study was to investigate whether early postnatal stress influences 5-HT1A receptor function in the medial prefrontal cortex in adult rats. Rats were subjected to aversive foot shock (FS) during the third week of the postnatal period (3wFS group). During the postadolescent period (10-14 weeks postnatal), immunohistochemical experiments were carried out to investigate c-Fos expression following the administration of R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a 5-HT1A receptor agonist. In the 3wFS group, the 8-OH-DPAT-induced c-Fos expression in the medial prefrontal cortex was significantly attenuated compared to that in the non-FS control group. A dual immunofluorescence study revealed that a small proportion of c-Fos positive cells co-express parvalbumin, and a relatively large proportion of c-Fos positive cells co-express glutaminase, suggesting that most c-Fos positive cells are glutamatergic neurons. We found that local perfusion of 8-OH-DPAT via a dialysis probe decreased extracellular 5-HT levels in the medial prefrontal cortex of the non-FS group, but not in the 3wFS group. However, the levels of 8-OH-DPAT-induced 5-HT syndrome were not significantly different between the non-FS and 3wFS groups. Therefore, aversive stress in the third week of the postnatal period attenuates 5-HT1A receptor function in the medial prefrontal cortex in adulthood and produces feedback inhibition of the raphe nuclei via postsynaptic 5-HT1A receptors.
出版者 en Elsevier B.V.
日付
    Issued2009-08-01
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/38931
関連
  • isVersionOf DOI https://doi.org/10.1016/j.ejphar.2009.05.012
  • PMID 19470384
収録誌情報
    • PISSN 0014-2999
      • en European Journal of Pharmacology
      • 巻615 号1-3 開始ページ76 終了ページ82
ファイル
コンテンツ更新日時 2023-07-26