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タイトル	en Predicting the Antigenic Structure of the Pandemic (H1N1) 2009 Influenza Virus Hemagglutinin
作成者	en Igarashi, Manabu NRID 1000010374240 en Ito, Kimihito NRID 1000060396314 en Yoshida, Reiko en Tomabechi, Daisuke en Kida, Hiroshi NRID 1000010109506 en Takada, Ayato NRID 1000010292062
アクセス権	open access
権利情報	http://creativecommons.org/licenses/by/2.5/ en Creative Commons Attribution
主題	NDC 493
内容注記	Abstract en The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hemagglutinin (HA) gene of 2009 H1N1 is derived from "classical swine H1N1" virus, which likely shares a common ancestor with the human H1N1 virus that caused the pandemic in 1918, whose descendant viruses are still circulating in the human population with highly altered antigenicity of HA. However, information on the structural basis to compare the HA antigenicity among 2009 H1N1, the 1918 pandemic, and seasonal human H1N1 viruses has been lacking. By homology modeling of the HA structure, here we show that HAs of 2009 H1N1 and the 1918 pandemic virus share a significant number of amino acid residues in known antigenic sites, suggesting the existence of common epitopes for neutralizing antibodies cross-reactive to both HAs. It was noted that the early human H1N1 viruses isolated in the 1930s-1940s still harbored some of the original epitopes that are also found in 2009 H1N1. Interestingly, while 2009 H1N1 HA lacks the multiple N-glycosylations that have been found to be associated with an antigenic change of the human H1N1 virus during the early epidemic of this virus, 2009 H1N1 HA still retains unique three-codon motifs, some of which became N-glycosylation sites via a single nucleotide mutation in the human H1N1 virus. We thus hypothesize that the 2009 H1N1 HA antigenic sites involving the conserved amino acids will soon be targeted by antibody-mediated selection pressure in humans. Indeed, amino acid substitutions predicted here are occurring in the recent 2009 H1N1 variants. The present study suggests that antibodies elicited by natural infection with the 1918 pandemic or its early descendant viruses play a role in specific immunity against 2009 H1N1, and provides an insight into future likely antigenic changes in the evolutionary process of 2009 H1N1 in the human population.
出版者	en Public Library of Science
日付	Issued2010-01-01
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/42563
関連	isIdenticalTo DOI https://doi.org/10.1371/journal.pone.0008553
収録誌情報	PISSN 1932-6203 en PLoS One 巻5 号1 開始ページe8553
ファイル	fulltext PLO5-1_e8553.pdf 2.58 MB (application/pdf) Issued2010-01-01
コンテンツ更新日時	2023-07-26