タイトル |
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en
The CYP1D subfamily of genes in mammals and other vertebrates.
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作成者 |
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アクセス権 |
open access |
権利情報 |
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en
The original publication is available at www.springerlink.com
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主題 |
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内容注記 |
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Abstract
en
Members of the cytochrome P450 family 1 (CYP1s) are involved in the detoxification and bioactivation of numerous environmental pollutants and phytochemicals, such as polycyclic aromatic hydrocarbons (PAHs), aromatic amines and flavonoids. The vertebrate CYP1 gene comprises four subfamilies, CYP1A, CYP1B, CYP1C and CYP1D. Recently, the CYP1D gene was identified in fish, and subsequently in the platypus. These findings indicate the possibility that all vertebrates have a functional CYP1D subfamily. However, there is no information on the mammalian CYP1D gene. In this study, we investigated the genomic location of CYP1D genes in mammals and other vertebrates in silico. We also performed phylogenetic analysis and calculated the identities and similarities of CYP1D sequences. The data from synteny and phylogenetic analyses of CYP1D genes demonstrated the evolutionary history of the CYP1 gene family. The results suggested that CYP1D became a non-functional pseudogene in human and bovine species; however, several other mammals possess functional CYP1D genes. The promoter regions of CYP1D genes were also examined. Unlike other CYP1 isoforms, few xenobiotic responsive element (XRE)-like sequences were found upstream of the CYP1D genes. Analysis of mammalian CYP1Ds also provided new insight into the relationship between CYP1 genes and the aryl hydrocarbon receptor.
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出版者 |
en
Springer
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日付 |
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言語 |
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資源タイプ |
journal article |
出版タイプ |
AM |
資源識別子 |
HDL
http://hdl.handle.net/2115/45756
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関連 |
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isVersionOf
DOI
https://doi.org/10.1007/s00335-010-9263-9
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PMID
20495808
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収録誌情報 |
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PISSN
0938-8990
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NCID
AA10839514
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en
Mammalian Genome
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巻21
号5-6
開始ページ320
終了ページ329
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ファイル |
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コンテンツ更新日時 |
2023-07-26 |