| タイトル |
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en
Study on the Sliding Friction of Endothelial Cells Cultured on Hydrogel and the Role of Glycocalyx on Friction Reduction
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
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Friction
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Other
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Endothelial cell
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Other
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Glycocalyx
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Other
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Gel scaffold
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Other
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Lubrication
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NDC
460
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| 内容注記 |
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Abstract
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In this study, we investigated the sliding friction of human umbilical vein endothelial cell (HUVEC) monolayer cultured on poly(sodium p-styrene sulfonate) (PNaSS) gel, intending to elucidate the role of the glycocalyx on the surface of endothelial cell (EC) in friction reduction. Three sets of HUVEC monolayers were investigated: 1) as-cultured HUVEC monolayer, 2) HUVEC monolayer treated by transforming growth factor υ1 (TGF-υ1), which increased glycocalyx by 148%, 3) HUVEC monolayer treated by heparinase I, which reduced glycocalyx by 57%, both were compared with that of the as prepared one. When being slid on flat glass surface, the frictional stress of HUVEC monolayer decreased in the order of heparinase I-treated > as-cultured > TGF-υ1-treated samples. The results suggested that glycocalyx may play a role in reducing the friction of endothelial cell monolayer.
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| 出版者 |
en
WILEY
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/44824
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1002/adem.201080021
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| 収録誌情報 |
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PISSN
1438-1656
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EISSN
1527-2648
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NCID
AA11613550
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en
Advanced Engineering Materials
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巻12
号11
開始ページB628
終了ページB636
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
