| タイトル |
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en
Furazolidone induces the activity of microsomal enzymes that metabolize furazolidone in chickens
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
Chicken
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Other
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Cytochrome P450
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Other
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Furazolidone
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Other
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Liver
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Other
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NADPH cytochrome P450 reductase
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NDC
649
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| 内容注記 |
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Abstract
en
The nitrofuran antibacterial agent furazolidone (FZ) is still used in veterinary medicine in some countries in the Middle and Far East. The present study aimed to show the effect of FZ on the activity of microsomal enzymes that metabolize FZ, and to identify the enzyme that contributes to FZ metabolism in chickens. Wistar rats and White Leghorn chickens were administered FZ once a day for 4 consecutive days. FZ metabolism was accelerated by FZ administration in chickens, but not in rats. The elevation of FZ metabolism coincided with the induction of NADPH cytochrome P450 reductase (CPR) activity in chickens, but such induction was not observed in rats. FZ metabolizing activities were inhibited in the presence of a CPR inhibitor (diphenylene iodonium chloride) but not by the addition of archetypal cytochrome P450 inhibitors (CO or n-octylamine). The preset study concluded that FZ accelerated its own metabolism in the chicken by induction of the activity of CPR.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/45809
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1016/j.pestbp.2011.02.013
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| 収録誌情報 |
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en
Pesticide Biochemistry and Physiology
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巻100
号2
開始ページ135
終了ページ139
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
