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タイトル
  • en Adjuvant surgical therapy for patients with initially-unresectable pancreatic cancer with long-term favorable responses to chemotherapy
作成者
アクセス権 open access
権利情報
  • en The original publication is available at www.springerlink.com
主題
  • Other en Unresectable pancreatic cancer
  • Other en Chemotherapy
  • Other en Adjuvant surgery
  • NDC 494
内容注記
  • Abstract en Background: To evaluate the prognostic impact of surgical intervention for initially-unresectable pancreatic ductal adenocarcinomas with long-term favorable responses to chemotherapy. Method: Twelve patients with initially-unresectable pancreatic ductal carcinomas who underwent radical surgery after a favorable response to chemotherapy for six months or longer in principle were enrolled in this study. We retrospectively reviewed the charts of these 12 patients and performed a survival analysis. Results: Initially, the included patients were unable to undergo resection secondary to locally-advanced disease in eight patients and metastatic disease in four patients. The length of preoperative therapy was five to 44 months (median 12). The operative procedure included resection of the area initially involved by tumor and regional major vessels. The postoperative mortality and morbidity rates were 0% and 50%, respectively. R0 resection was achieved in nine patients (75%) and pathological CR was seen in one patient. Estimated overall five-year survival from initial therapy was 50.0%. The survival rate (0% at 5 years) of the four patients with metastatic disease as the cause of initial unresectability was significantly worse than that (100% at 5 years) of the eight patients with locally-advanced disease (P = 0.0014). Conclusion: Surgical intervention should be considered for patients with initially-unresectable pancreatic cancers who demonstrate long-term favorable responses to chemotherapy. R0 resection may significantly contribute to cure, especially in patients with initially locally-advanced disease. Large cohort prospective studies will be necessary to demonstrate the efficacy of this strategy.
出版者 en Springer Japan
日付
    Issued2011-09
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/47042
関連
  • isVersionOf DOI https://doi.org/10.1007/s00534-011-0391-8
  • PMID 21455748
収録誌情報
    • PISSN 1868-6974
      • en Journal of Hepato-Biliary-Pancreatic Sciences
      • 巻18 号5 開始ページ712 終了ページ716
ファイル
コンテンツ更新日時 2023-07-26