| タイトル |
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en
Diazepam-Induced Increases of Synaptic Efficacy in the Hippocampal-Medial Prefrontal Cortex Pathway Are Associated With Its Anxiolytic-like Effect in Rats
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
electrophysiology
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Other
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hippocampal-medial prefrontal cortex (mPFC) pathway
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Other
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behavior
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Other
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anxiety
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Other
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prefrontal cortex
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NDC
499
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| 内容注記 |
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Abstract
en
The medial prefrontal cortex (mPFC) has recently been shown to be an important brain region for emotional function as well as cognitive ability. In previous experiments, we studied the population spike amplitude (PSA) in the mPFC induced by stimulation of the CA1/subicular region as an index of synaptic efficacy in the hippocampal-mPFC pathway. In the present study, we investigated the relationship between the anxiolytic effect of diazepam and the changes of synaptic efficacy in this pathway. In contextual fear conditioning tests, diazepam (0.1 mg/kg) was not effective for fear-related freezing behavior. At a dose of 0.5 mg/kg, diazepam decreased freezing behavior 20 min after administration, with no discernible effect 30 min after administration. In electrophysiological experiments, 0.1 mg/kg diazepam had no effect on the PSA in the mPFC. In contrast, 0.5 mg/kg diazepam increased the PSA in the mPFC within 30 min of administration; however, this PSA increase was attenuated over the 30-min period. Based on these results, we propose that the diazepam-induced PSA increase in the mPFC is associated with its anxiolytic-like effect.
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| 出版者 |
en
Japanese Pharmacological Society
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/47360
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| 関連 |
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URI
http://www.jstage.jst.go.jp/browse/jphs
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isVersionOf
DOI
https://doi.org/10.1254/jphs.10182FP
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| 収録誌情報 |
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PISSN
1347-8613
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EISSN
1347-8648
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en
Journal of Pharmacological Sciences
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巻114
号3
開始ページ341
終了ページ346
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
