Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population

Horie Yukihiro; Meguro Akira; Kitaichi Nobuyoshi; Lee Eun Bong; Kanda Atsuhiro; Noda Kousuke; Song Yeong Wook; Park Kyung Sook; Namba Kenichi; Ota Masao; Inoko Hidetoshi; Mizuki Nobuhisa; Ishida Susumu; Ohno Shigeaki

タイトル	en Replication of a microsatellite genome-wide association study of Behçet's disease in a Korean population
作成者	en Horie, Yukihiro en Meguro, Akira en Kitaichi, Nobuyoshi NRID 1000040431366 en Lee, Eun Bong en Kanda, Atsuhiro en Noda, Kousuke NRID 1000090296666 en Song, Yeong Wook en Park, Kyung Sook en Namba, Kenichi NRID 1000070333599 en Ota, Masao en Inoko, Hidetoshi en Mizuki, Nobuhisa en Ishida, Susumu NRID 1000010245558 en Ohno, Shigeaki NRID 1000050002382
アクセス権	open access
権利情報	en This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version, Rheumatology (2012) 51 (6): 983-986, is available online at: http://rheumatology.oxfordjournals.org/content/51/6/983
主題	Other en microsatellite Other en GWAS Other ja Behçet's disease Other en replication study Other en HLA-B Other en Korean NDC 493
内容注記	Abstract en Objective: Behcet disease is one of the major etiologies of uveitis causing blindness in Asian countries. A genome-wide association study identified 6 microsatellite markers as disease susceptibility loci for Japanese patients with Behcet disease. To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study. Methods: Study participants included 119 Behcet patients and 141 controls. All were enrolled in Korea. Association between the 6 reported microsatellite markers (D3S0186i, D6S0014i, D6S0032i, 536G12A, D12S0645i, and D22S0104i) and Behcet disease was analysed. HLA-B was genotyped by sequence-based typing methods. Results: A microsatellite marker located near the HLA-B region demonstrated significant association with Behcet disease (P = 0.028). The genotype and phenotype frequencies of the HLA-B51 gene were significantly increased in patients (23.1% and 39.5%, respectively) compared with healthy controls (11.2% and 20.1%, respectively; P < 0.001). Conclusions: Microsatellite analysis revealed that the HLA-B51 gene was strongly associated with Behcet disease in a Korean population.
出版者	en Oxford University Press
日付	Issued2012-06
言語	eng
資源タイプ	journal article
出版タイプ	AM
資源識別子	HDL http://hdl.handle.net/2115/51366
関連	isVersionOf DOI https://doi.org/10.1093/rheumatology/ker444 PMID 22258392
収録誌情報	PISSN 1462-0324 en Rheumatology 巻51 号6 開始ページ983 終了ページ986
ファイル	fulltext Rhe51-6_983-986.pdf 260.06 KB (application/pdf) Issued2012-06
コンテンツ更新日時	2023-07-26