| タイトル |
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en
Tunneling nanotubes: Emerging view of their molecular components and formation mechanisms
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
Tunneling nanotubes
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Other
en
Membrane nanotubes
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Other
en
Cytonemes
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Other
en
M-Sec (TNFaip2)
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Other
en
Intercellular communication
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NDC
463
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| 内容注記 |
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Abstract
en
Cell-to-cell communication is essential for the development and maintenance of multicellular organisms. The tunneling nanotube (TNT) is a recently recognized distinct type of intercellular communication device. TNTs are thin protrusions of the plasma membrane and allow direct physical connections of the plasma membranes between remote cells. The proposed functions for TNTs include the cell-to-cell transfer of large cellular structures such as membrane vesicles and organelles, as well as signal transduction molecules in a wide variety of cell types. Moreover TNT and TNT-related structures are thought to facilitate the intercellular spreading of virus and/or pathogenic proteins. Despite their contribution to normal cellular functions and importance in pathological conditions, virtually nothing is known about the molecular basis for their formation. We have recently shown that M-Sec (also called TNFaip2) is a key molecule for TNT formation. In cooperation with the RalA small GTPase and the exocyst complex, M-Sec can induce the formation of functional TNTs, indicating that the remodeling of the actin cytoskeleton and vesicle trafficking are involved in M-Sec-mediated TNT formation. Discovery of the role of M-Sec will accelerate our understanding of TNTs, both at the molecular and physiological levels.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/50688
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1016/j.yexcr.2012.05.013
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PMID
22652450
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| 収録誌情報 |
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-
en
Experimental Cell Research
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巻318
号14
開始ページ1699
終了ページ1706
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
