| タイトル |
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en
Milnacipran enhances the control of impulsive action by activating D1-like receptors in the infralimbic cortex
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
The original publication is available at www.springerlink.com
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| 主題 |
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Other
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Response inhibition
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Other
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Inhibitory control
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Other
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Ventromedial prefrontal cortex
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Other
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Suicide
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Other
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Addiction
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Other
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Five-choice serial reaction time task
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NDC
493
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| 内容注記 |
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Abstract
en
Rationale: Elevated impulsivity is often observed in patients with depression. We recently found that milnacipran, an antidepressant and a serotonin/noradrenaline reuptake inhibitor, could enhance impulse control in rats. However, the neural mechanisms underlying the effects of milnacipran on impulsive action remain unclear. Milnacipran increases not only extracellular serotonin and noradrenaline but also dopamine specifically in the medial prefrontal cortex, which is one of brain regions responsible for impulsive action. Objectives: Our goal was to identify whether D1-like and/or D2-like receptors in the infralimbic cortex (IL), the ventral portion of the medial prefrontal cortex, mediates the milnacipran-enhanced impulse control in a three-choice serial reaction time task. Methods: The rats were bilaterally injected with SCH23390, a selective D1-like receptor antagonist (0.3 or 3 ng/side) or eticlopride, a selective D2-like receptor antagonist (0.3 or 1 μg/side) into the IL after acute intraperitoneal administration of milnacipran (10 mg/kg). Results: Intra-IL SCH23390 injections reversed the milnacipran-enhanced impulse control, whereas injections of eticlopride into the IL failed to block the effects of milnacipran on impulsive action. Conclusions: This is the first report that demonstrates a critical role for D1-like receptors of the IL in milnacipran-enhanced control of impulsive action.
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| 出版者 |
en
Springer-Verlag
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/54108
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1007/s00213-012-2835-5
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PMID
22892727
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| 収録誌情報 |
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en
Psychopharmacology
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巻225
号2
開始ページ495
終了ページ504
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
