| タイトル |
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en
Osteoconductivity and Biodegradability of Collagen Scaffold Coated with Nano-β-TCP and Fibroblast Growth Factor 2
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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| 内容注記 |
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Abstract
en
Nanoparticle bioceramics have become anticipated for biomedical applications.Highly bioactive and biodegradable scaffoldswould be developed using nanoparticles of ?-tricalcium phosphate (?-TCP).We prepared collagen scaffolds coated by nano-?-TCP and fibroblast growth factor 2 (FGF2) and evaluated the effects on new bone augmentation and biodegradation. The collagen sponge was coated with the nano-TCP dispersion and freeze-dried. Scaffold was characterized by SEM, TEM, XRD, compressive testing and cell seeding. Subsequently, the nano-?-TCP/collagen scaffold, collagen sponge, and each material loaded with FGF2 were implanted on rat cranial bone. As a control, no implantation was performed. Nano-TCP particles were found to be attached to the fibers of the collagen sponge by SEM and TEM observations. Scaffold coated with nano-TCP showed higher compressive strength and cytocompatibility. In histological evaluations at 10 days, inflammatory cells were rarely seen around the residual scaffold, suggesting that the nano-TCPmaterial possesses good tissue compatibility. At 35 days, bone augmentation and scaffold degradation in histological samples receiving nano-?-TCP scaffold were significantly greater than those in the control. By loading of FGF2, advanced bone formation is facilitated, indicating that a combination with FGF2 would be effective for bone tissue engineering.
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| 出版者 |
en
Hindawi Publishing Corporation
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/52991
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| 関連 |
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isIdenticalTo
DOI
https://doi.org/10.1155/2013/639502
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| 収録誌情報 |
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PISSN
1687-4110
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EISSN
1687-4129
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en
Journal of Nanomaterials
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巻2013
開始ページ1
終了ページ11
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
