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タイトル
  • en A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication
作成者
アクセス権 open access
主題
  • Other en Nanoparticle-targeted proapoptotic peptide
  • Other en Adipotide
  • Other en Diet-induced obesity
  • Other en Metabolic syndrome
  • Other en Ectopic fat
  • Other en Antiangiogenesis
  • NDC 499
内容注記
  • Abstract en Antiangiogenesis has been the focus of a new strategy for the treatment of obesity. However, little is known regarding the issue of whether targeting angiogenesis by nanoparticle-targeted therapeutic is advantageous or not in debugging the co-morbidity associated with diet-induced obesity (DIO) and the metabolic syndrome. We report herein on the positive effect of prohibitin (an adipose vascular marker)-targeted nanoparticle (PTNP) encapsulated in a proapoptotic peptide [(D)(KLAKLAK)(2), KLA] on DIO and dysfunctional adipose tissue, a major mediator of the metabolic syndrome, as evidenced by ectopic fat deposition. The systemic injection of DIO mice with a low dose of KLA-PTNP, rather than a bioconjugate composed of the same targeting peptide and KLA (Adipotide) resulted in a reduction in body weight, as evidenced by a significant decrease in serum leptin levels, in parallel with an antiobesity effect on dysfunctional adipose cells, including adipocytes and macrophages. In addition, the KLA-PTNP treatment resulted in a reduction in ectopic fat deposits in liver and muscle with the lipolytic action of elevated serum adiponectin, with no detectable hepatoxicity. Notably, drug delivery via PTNP that had accumulated in obese fat via the enhanced permeability and retention effect was enhanced by multivalent active targeting and cytoplasmic delivery into adipose endothelial cells via escaping from endosomes/lysosomes. Thus, vascular-targeted nanotherapy has the potential to contribute to the control of adipose function and ectopic fat deposition associated with obesity and the metabolic syndrome. (C) 2013 Elsevier B. V. All rights reserved.
出版者 en Elsevier science bv
日付
    Issued2013-10-28
言語
  • eng
資源タイプ journal article
出版タイプ AM
資源識別子 HDL http://hdl.handle.net/2115/54123
関連
  • isVersionOf DOI https://doi.org/10.1016/j.jconrel.2013.07.013
  • PMID 23871959
収録誌情報
    • PISSN 0168-3659
      • en Journal of controlled release
      • 171 2 開始ページ104 終了ページ112
ファイル
コンテンツ更新日時 2023-07-26