| タイトル |
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en
PTHrP promotes malignancy of human oral cancer cell downstream of the EGFR signaling
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
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PTHrP
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Other
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EGFR
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Other
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AG1478
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Other
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RNA interference
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Other
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Oral cancer
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Other
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Therapeutics
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NDC
490
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| 内容注記 |
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Abstract
en
Parathyroid hormone-related protein (PTHrP) is detected in many aggressive tumors and involved in malignant conversion; however, the underlying mechanism remains obscure. Here, we identified PTHrP as a mediator of epidermal growth factor receptor (EGFR) signaling to promote the malignancies of oral cancers. PTHrP mRNA was abundantly expressed in most of the quiescent oral cancer cells, and was significantly upregulated by EGF stimulation via ERK and p38 MAPK. PTHrP silencing by RNA interference, as well as EGFR inhibitor AG1478 treatment, significantly suppressed cell proliferation, migration, and invasiveness. Furthermore, combined treatment of AG1478 and PTHrP knockdown achieved synergistic inhibition of malignant phenotypes. Recombinant PTHrP substantially promoted cell motility, and rescued the inhibition by PTHrP knockdown, suggesting the paracrine/autocrine function of PTHrP. These data indicate that PTHrP contributes to the malignancy of oral cancers downstream of EGFR signaling, and may thus provide a therapeutic target for oral cancer.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/54567
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1016/j.bbrc.2008.01.121
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PMID
18261460
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| 収録誌情報 |
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PISSN
0006-291X
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NCID
AA00564395
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en
Biochemical and Biophysical Research Communications
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巻368
号3
開始ページ575
終了ページ581
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
