Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice

Nakayama Yosuke; Moriya Tomohiro; Sakai Fumihiko; Ikeda Noriko; Shiozaki Takuya; Hosoya Tomohiro; Nakagawa Hisako; Miyazaki Tadaaki

タイトル	en Oral administration of Lactobacillus gasseri SBT2055 is effective for preventing influenza in mice
作成者	en Nakayama, Yosuke en Moriya, Tomohiro en Sakai, Fumihiko en Ikeda, Noriko en Shiozaki, Takuya en Hosoya, Tomohiro en Nakagawa, Hisako en Miyazaki, Tadaaki NRID 1000060272431
アクセス権	open access
権利情報	http://creativecommons.org/licenses/by/3.0/ en Creative Commons Attribution 3.0 Unported
主題	NDC 490
内容注記	Abstract en The Lactobacillus gasseri SBT2055 (LG2055) is a probiotic lactic acid bacterium with properties such as bile tolerance and ability to improve the intestinal environment. In this study, we established that the oral administration of LG2055 exhibits efficacy to protect mice infected with the influenza virus A/PR8. The body weight losses were lower with the LG2055 administration after the PR8 virus infection. At 5 days after the infection, the virus titer was significantly decreased as was the amount of produced IL-6 in the lung tissue, the number of total cells in the bronchoalveolar lavage fluid was reduced by the LG2055 administration. The expression of the Mx1 and Oas1a genes, critical for the viral clearance in the lung tissues was increased by the pre-treatment with LG2055. These findings suggest that the LG2055 administration is effective for the protection against influenza A virus infection by the down-regulation of viral replication through the induction of antiviral genes expression.
出版者	en Nature Publishing Group
日付	Issued2014-04-10
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/55893
関連	isIdenticalTo DOI https://doi.org/10.1038/srep04638 PMID 24717726
収録誌情報	PISSN 2045-2322 en Scientific Reports 巻4 開始ページ4638
ファイル	fulltext Sci Rep_4_4638.pdf 485.8 KB (application/pdf) Issued2014-04-10
コンテンツ更新日時	2023-07-26