| タイトル |
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en
Overexpression of TNF-α converting enzyme promotes adipose tissue inflammation and fibrosis induced by high fat diet
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| 作成者 |
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| アクセス権 |
open access |
| 主題 |
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Other
en
Adipose tissue inflammation
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Other
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High fat diet
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Other
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Obesity
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Other
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TACE
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Other
ja
TNF-α
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NDC
491
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| 内容注記 |
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Abstract
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Obesity is a state in which chronic low-grade inflammation persists in adipose tissues. Pro-inflammatory cytokines, including TNF-α, produced by adipose tissues have been implicated as active participants in the development of obesity-related diseases. Since TNF-α converting enzyme (TACE) is the major factor that induces soluble TNF-α, TACE has been noted as a pivotal regulator in this field. To reveal the role of TACE in adipose tissue inflammation, TACE-transgenic (TACE-Tg) and wild type (WT) mice were fed with high fat diet (HFD) or control diet for 16 weeks. At 13 weeks after the beginning of the diet, serum TNF-α and macrophage-related cytokine/chemokine levels were elevated in TACE-Tg mice fed with HFD (Tg-HFD mice), and the number of the so-called crown-like adipocyte was significantly increased in adipose tissues of Tg-HFD mice at the end of the experiment. Although macrophage infiltration was not detected in the adipose tissues at this time, fibrosis was observed around the crown-like adipocytes. These findings suggested that TACE overexpression induced macrophage infiltration and subsequent fibrosis in adipose tissues under HFD regimen. The collective evidence suggested that TACE could be a therapeutic target of HFD-induced obesity-related adipose tissue inflammation.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/57002
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1016/j.yexmp.2014.09.017
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PMID
25236578
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| 収録誌情報 |
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en
Experimental and Molecular Pathology
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巻97
号3
開始ページ354
終了ページ358
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
