Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children

Mitsui Takahiko; Araki Atsuko; Imai Ayako; Sato Sakiko; Miyashita Chihiro; Ito Sachiko; Sasaki Seiko; Kitta Takeya; Moriya Kimihiko; Cho Kazutoshi; Morioka Keita; Kishi Reiko; Nonomura Katsuya

タイトル	en Effects of Prenatal Leydig Cell Function on the Ratio of the Second to Fourth Digit Lengths in School-Aged Children
作成者	en Mitsui, Takahiko NRID 1000090421966 en Araki, Atsuko NRID 1000000619885 en Imai, Ayako en Sato, Sakiko en Miyashita, Chihiro en Ito, Sachiko en Sasaki, Seiko NRID 1000030448831 en Kitta, Takeya NRID 1000040374441 en Moriya, Kimihiko NRID 1000020374233 en Cho, Kazutoshi NRID 1000010312365 en Morioka, Keita en Kishi, Reiko NRID 1000080112449 en Nonomura, Katsuya NRID 1000060113750
アクセス権	open access
権利情報	http://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
主題	NDC 490
内容注記	Abstract en Prenatal sex hormones can induce abnormalities in the reproductive system and adversely impact on genital development. We investigated whether sex hormones in cord blood influenced the ratio of the second to fourth digit lengths (2D/4D) in school-aged children. Of the 514 children who participated in a prospective cohort study on birth in Sapporo between 2002 and 2005, the following sex hormone levels were measured in 294 stored cord blood samples (135 boys and 159 girls); testosterone (T), estradiol (E), progesterone, LH, FSH, inhibin B, and insulin-like factor 3 (INSL3). A total of 350 children, who were of school age and could be contacted for this survey, were then requested via mail to send black-and-white photocopies of the palms of both the left and right hands. 2D/4D was calculated in 190 children (88 boys and 102 girls) using photocopies and derived from participants with the characteristics of older mothers, a higher annual household income, higher educational level, and fewer smokers among family members. 2D/4D was significantly lower in males than in females (p<0.01). In the 294 stored cord blood samples, T, T/E, LH, FSH, Inhibin B, and INSL3 levels were significantly higher in samples collected from males than those from females. A multivariate regression model revealed that 2D/4D negatively correlated with INSL3 in males and was significantly higher in males with <0.32 ng/mL of INSL3 (p<0.01). No correlations were observed between other hormones and 2D/4D. In conclusion, 2D/4D in school-aged children, which was significantly lower in males than in females, was affected by prenatal Leydig cell function.
出版者	en Public Library Science
日付	Issued2015-03-06
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/58951
関連	isIdenticalTo DOI https://doi.org/10.1371/journal.pone.0120636
収録誌情報	PISSN 1932-6203 en Plos one 巻10 号3 開始ページe0120636
ファイル	fulltext fetchObject.pdf 203.2 KB (application/pdf) Issued2015-03-06
コンテンツ更新日時	2023-07-26