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タイトル	en The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ
作成者	en Watanabe, Masashi en Takahashi, Hidehisa NRID 1000030423544 en Saeki, Yasushi NRID 1000080462779 en Ozaki, Takashi en Itoh, Shihori en Suzuki, Masanobu en Mizushima, Wataru en Tanaka, Keiji NRID 1000020002313 en Hatakeyama, Shigetsugu NRID 1000070294973
アクセス権	open access
権利情報	http://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
主題	NDC 490
内容注記	Abstract en Adipocyte differentiation is a strictly controlled process regulated by a series of transcriptional activators. Adipogenic signals activate early adipogenic activators and facilitate the transient formation of early enhanceosomes at target genes. These enhancer regions are subsequently inherited by late enhanceosomes. PPAR gamma is one of the late adipogenic activators and is known as a master regulator of adipogenesis. However, the factors that regulate PPAR gamma expression remain to be elucidated. Here, we show that a novel ubiquitin E3 ligase, tripartite motif protein 23 (TRIM23), stabilizes PPAR gamma protein and mediates atypical polyubiquitin conjugation. TRIM23 knockdown caused a marked decrease in PPAR gamma protein abundance during preadipocyte differentiation, resulting in a severe defect in late adipogenic differentiation, whereas it did not affect the formation of early enhanceosomes. Our results suggest that TRIM23 plays a critical role in the switching from early to late adipogenic enhanceosomes by stabilizing PPAR gamma protein possibly via atypical polyubiquitin conjugation.
出版者	en eLife Sciences Publications
日付	Issued2015-04-23
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/59433
関連	isIdenticalTo DOI https://doi.org/10.7554/eLife.05615
収録誌情報	PISSN 2050-084X en Elife 巻4 開始ページe05615
ファイル	fulltext e05615.full.pdf 10.79 MB (application/pdf) Issued2015-04-23
コンテンツ更新日時	2023-07-26