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タイトル
  • en Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice
作成者
    • en Takano, Hironobu
    • en Kushibiki, Toshihiro
    • en Hontani, Kouji
    • en Inoko, Kazuho
    • en Takahashi, Mizuna
    • en Sato, Shoki
    • en Abe, Hirotake
    • en Takeuchi, Shintaro
    • en Sato, Nagato
    • en Hiraoka, Kei
アクセス権 open access
権利情報
主題
  • Other en EphA4
  • Other en prognostic factor
  • Other en 2,5-dimethylpyrrolyl benzoic acid
  • Other en human pancreatic cancer
  • Other en orthotopic models
  • NDC 490
内容注記
  • Abstract en Ephrin receptor A4 (EphA4) is overexpressed in human pancreatic adenocarcinoma (PDAC) and activate cell growth. Recent studies have identified small molecules that block EphA4. In this study, we investigated the correlation between EphA4 expression and the prognosis of patients with PDAC. We also examined the cytostatic efficacy of 2,5-dimethylpyrrolyl benzoic acid (compound 1), a small molecule that blocks EphA4, in PDAC cells. Overall survival of patients with EphA4 positivity was significantly shorter than that of patients with EphA4 negativity (P = 0.029). In addition, multivariate analysis revealed that EphA4 expression was an independent prognostic factor in PDAC patients (P = 0.039). Compound 1 showed a cytostatic efficacy in PDAC cells expressing EphA4 in vitro and in vivo. Our study indicated that compound 1 suppressed both EphA4 and Akt phosphorylations, and induced apoptosis in PDAC cells expressing EphA4. In conclusion, compound 1 has a high potential as a therapeutic agent for patients with PDAC.
出版者 en Impact Journals
日付
    Issued2015-10-19
言語
  • eng
資源タイプ journal article
出版タイプ VoR
資源識別子 HDL http://hdl.handle.net/2115/60647
関連
  • isIdenticalTo DOI https://doi.org/10.18632/oncotarget.5729
収録誌情報
    • PISSN 1949-2553
      • en Oncotarget
      • 6 38 開始ページ41063 終了ページ41076
ファイル
コンテンツ更新日時 2023-07-26