タイトル |
-
en
Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice
|
作成者 |
|
アクセス権 |
open access |
権利情報 |
|
主題 |
-
Other
en
EphA4
-
Other
en
prognostic factor
-
Other
en
2,5-dimethylpyrrolyl benzoic acid
-
Other
en
human pancreatic cancer
-
Other
en
orthotopic models
-
NDC
490
|
内容注記 |
-
Abstract
en
Ephrin receptor A4 (EphA4) is overexpressed in human pancreatic adenocarcinoma (PDAC) and activate cell growth. Recent studies have identified small molecules that block EphA4. In this study, we investigated the correlation between EphA4 expression and the prognosis of patients with PDAC. We also examined the cytostatic efficacy of 2,5-dimethylpyrrolyl benzoic acid (compound 1), a small molecule that blocks EphA4, in PDAC cells. Overall survival of patients with EphA4 positivity was significantly shorter than that of patients with EphA4 negativity (P = 0.029). In addition, multivariate analysis revealed that EphA4 expression was an independent prognostic factor in PDAC patients (P = 0.039). Compound 1 showed a cytostatic efficacy in PDAC cells expressing EphA4 in vitro and in vivo. Our study indicated that compound 1 suppressed both EphA4 and Akt phosphorylations, and induced apoptosis in PDAC cells expressing EphA4. In conclusion, compound 1 has a high potential as a therapeutic agent for patients with PDAC.
|
出版者 |
en
Impact Journals
|
日付 |
|
言語 |
|
資源タイプ |
journal article |
出版タイプ |
VoR |
資源識別子 |
HDL
http://hdl.handle.net/2115/60647
|
関連 |
-
isIdenticalTo
DOI
https://doi.org/10.18632/oncotarget.5729
|
収録誌情報 |
-
-
en
Oncotarget
-
巻6
号38
開始ページ41063
終了ページ41076
|
ファイル |
|
コンテンツ更新日時 |
2023-07-26 |