| タイトル |
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The effect of ovariectomy on urethral continence mechanisms during sneeze reflex in middle-aged versus young adult rats
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
This is the peer reviewed version of the following article: Neurourology and Urodynamics, Volume 35, Issue 1, pages 122–127, 2016, which has been published in final form at http://dx.doi.org/10.1002/nau.22690. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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| 主題 |
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Other
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stress urinary incontinence
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Other
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ovariectomy
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Other
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sneeze
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Other
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rat
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Other
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apoptosis
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NDC
490
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| 内容注記 |
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Abstract
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Aims: Stress urinary incontinence (SUI) is common in post-menopausal women. The present study therefore examined how aging and estrogen deficiency induced by ovariectomy (OVX) affect the urethral continence mechanism that prevents sneeze-induced SUI in rats. Methods: Young (3 months old) and middle-aged (12 months old) female rats underwent bilateral OVX or sham operation. Urethral activity was measured by the amplitude of urethral responses during sneezing (A-URS) and urethral baseline pressure (UBP). Apoptotic changes in urethral tissue sections were examined by the TUNEL method. Results: In middle-aged rats, UBP, but not A-URS, was significantly decreased compared to young rats. In 3-week OVX rats, A-URS was significantly decreased compared to sham rats in both young and middle-aged groups, and the OVX-induced reduction in A-URS was more pronounced in middle-aged rats. Neither young 3-week OVX nor sham rats leaked during sneezing; however, SUI occurred in 2/8 middle-aged rats with 3-week OVX, and after 6 weeks of OVX, SUI was observed in 5/8 young rats and 6/8 middle-aged rats. In middle-aged rats, TUNEL positive cells were significantly increased in urethral striated muscles whereas, after OVX, the increased number of positive cells was also found in the mucosa. Conclusions: These results indicate that aging is more likely to impair baseline urethral function than striated muscle-mediated reflex activity although apoptotic changes are found in urethral striated muscle. Estrogen deficiency additionally impairs the striated muscle-mediated continence reflex. Thus, aging and estrogen deficiency differently and additively affect baseline urethral function and neurally-evoked, striated muscle-mediated urethral continence mechanisms to induce SUI.
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| 出版者 |
en
Wiley-Blackwell
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/63973
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1002/nau.22690
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PMID
25358967
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| 収録誌情報 |
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PISSN
0733-2467
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NCID
AA10631557
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Neurourology and Urodynamics
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巻35
号1
開始ページ122
終了ページ127
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
