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タイトル	en The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
その他のタイトル	en RIG-I functions as a dual effector against HBV
作成者	en Sato, Seiichi en Li, Kai en Kameyama, Takeshi NRID 1000040569505 en Hayashi, Takaya en Ishida, Yuji en Murakami, Shuko NRID 1000050454848 en Watanabe, Tsunamasa NRID 1000020338528 en Iijima, Sayuki NRID 1000000416273 en Sakurai, Yu en Watashi, Koichi NRID 1000040378948 en Tsutsumi, Susumu en Sato, Yusuke NRID 1000010735624 en Akita, Hidetaka NRID 1000080344472 en Wakita, Takaji NRID 1000040280789 en Rice, CharlesM. en Harashima, Hideyoshi NRID 1000000183567 en Kohara, Michinori NRID 1000010250218 en Tanaka, Yasuhito NRID 1000090336694 en Takaoka, Akinori NRID 1000030323611
アクセス権	open access
権利情報	en © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ en Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
主題	NDC 490
内容注記	Other en Supplemental materials are available on the publisher's website. Abstract en Host innate recognition triggers key immune responses for viral elimination. The sensing mechanism of hepatitis B virus (HBV), a DNA virus, and the subsequent downstream signaling events remain to be fully clarified. Here we found that type III but not type I interferons are predominantly induced in human primary hepatocytes in response to HBV infection, through retinoic acid-inducible gene-I (RIG-I)-mediated sensing of the 5'-ε region of HBV pregenomic RNA. In addition, RIG-I could also counteract the interaction of HBV polymerase (P protein) with the 5'-ε region in an RNA-binding dependent manner, which consistently suppressed viral replication. Liposome-mediated delivery and vector-based expression of this ε region-derived RNA in liver abolished the HBV replication in human hepatocyte-chimeric mice. These findings identify an innate recognition mechanism by which RIG-I dually functions as an HBV sensor activating innate signaling and to counteract viral polymerase in human hepatocytes.
出版者	en Cell Press
日付	Issued2015-01-20
言語	eng
資源タイプ	journal article
出版タイプ	AM
資源識別子	HDL http://hdl.handle.net/2115/62620
関連	isVersionOf DOI https://doi.org/10.1016/j.immuni.2014.12.016 PMID 25557055
収録誌情報	PISSN 1074-7613 en Immunity 巻42 号1 開始ページ123 終了ページ132
ファイル	fulltext Immunity42_123.pdf 3.78 MB (application/pdf) Issued2015-01-20
コンテンツ更新日時	2023-07-26