| タイトル |
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en
Relevance of signaling molecules for apoptosis induction on influenza A virus replication
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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en
© 2013. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
- http://creativecommons.org/licenses/by-nc-nd/4.0/
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en
Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
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| 主題 |
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Other
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Influenza A virus
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Other
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Apoptosis
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Other
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Signal transduction
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NDC
491
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| 内容注記 |
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Abstract
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Apoptosis is an important mechanism to maintain homeostasis in mammals, and disruption of the apoptosis regulation mechanism triggers a range of diseases, such as cancer, autoimmune diseases, and developmental disorders. The severity of influenza A virus (IAV) infection is also closely related to dysfunction of apoptosis regulation. In the virus infected cells, the functions of various host cellular molecules involved in regulation of induction of apoptosis are modulated by IAV proteins to enable effective virus replication. The modulation of the intracellular signaling pathway inducing apoptosis by the IAV infection also affects extracellular mechanisms controlling apoptosis, and triggers abnormal host responses related to the disease severity of IAV infections. This review focuses on apoptosis related molecules involved in IAV replication and pathogenicity, the strategy of the virus propagation through the regulation of apoptosis is also discussed.
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| 出版者 |
en
Elsevier
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
AM |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/63431
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| 関連 |
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isVersionOf
DOI
https://doi.org/10.1016/j.bbrc.2013.10.100
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| 収録誌情報 |
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PISSN
0006-291X
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NCID
AA00564395
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en
Biochemical and Biophysical Research Communications
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巻441
号3
開始ページ531
終了ページ537
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
