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タイトル
  • en Correlation between Pupil Size and Subjective Passage of Time in Non-Human Primates
作成者
アクセス権 open access
権利情報
主題
  • Other en eye movements
  • Other en monkeys
  • Other en pupil diameter
  • Other en self-timing
  • Other en temporal processing
  • NDC 490
内容注記
  • Abstract en Our daily experience of time is strongly influenced by internal states, such as arousal, attention, and mood. However, the underlying neuronal mechanism remains largely unknown. To investigate this, we recorded pupil diameter, which is closely linked to internal factors and neuromodulatory signaling, in monkeys performing the oculomotor version of the time production paradigm. In the self-timed saccade task, animals were required to make a memory-guided saccade during a predetermined time interval following a visual cue. We found that pupil diameter was negatively correlated with trial-by-trial latency of self-timed saccades. Because no significant correlation was found for visually guided saccades, correlation of self-timed saccades could not be explained solely by the facilitation of saccade execution. As the reward amount was manipulated, pupil diameter and saccade latency altered in opposite directions and the magnitudes of modulation correlated strongly across sessions, further supporting the close link between pupil diameter and the subjective passage of time. When the animals were trained to produce two different intervals depending on the instruction, the pupil size again correlated with the trial-by-trial variation of saccade latency in each condition; however, pupil diameter differed significantly for saccades with similar latencies generated under different conditions. Our results indicate that internal brain states indexed by pupil diameter, which parallel noradrenergic neuronal activity (Aston-Jones and Cohen, 2005), may bias trial-by-trial variation in the subjective passage of time.
出版者 en Society for Neuroscience
日付
    Issued2016-11-02
言語
  • eng
資源タイプ journal article
出版タイプ VoR
資源識別子 HDL http://hdl.handle.net/2115/65200
関連
  • isIdenticalTo DOI https://doi.org/10.1523/JNEUROSCI.2533-16.2016
  • PMID 27807173
収録誌情報
    • PISSN 0270-6474
      • en Journal of neuroscience
      • 36 44 開始ページ11331 終了ページ11337
ファイル
    • fulltext 11331.full.pdf
    • 689.51 KB (application/pdf)
      • Issued2016-11-02
コンテンツ更新日時 2023-07-26