Usefulness of PET/CT for early detection of internal malignancies in patients with Muir-Torre syndrome : report of two cases

Ishiguro Yui; Homma Shigenori; Yoshida Tadashi; Ohno Yosuke; Ichikawa Nobuki; Kawamura Hideki; Hata Hiroo; Kase Satoru; Ishida Susumu; Okada-Kanno Hiromi; Hatanaka Kanako C.; Taketomi Akinobu

タイトル	en Usefulness of PET/CT for early detection of internal malignancies in patients with Muir-Torre syndrome : report of two cases
作成者	en Ishiguro, Yui en Homma, Shigenori NRID 1000030533674 en Yoshida, Tadashi NRID 1000070772333 en Ohno, Yosuke en Ichikawa, Nobuki NRID 1000050779890 en Kawamura, Hideki NRID 1000070645960 en Hata, Hiroo en Kase, Satoru NRID 1000060374394 en Ishida, Susumu NRID 1000010245558 en Okada-Kanno, Hiromi en Hatanaka, Kanako C. en Taketomi, Akinobu NRID 1000070363364
アクセス権	open access
権利情報	https://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
主題	Other en Muir-Torre syndrome Other en PET/CT Other en Sebaceous carcinoma Other en Internal malignancy NDC 490
内容注記	Abstract en Background: Muir-Torre syndrome (MTS) is a rare autosomal dominant genodermatosis caused by mutations in mismatch repair genes. It is characterized by the presence of at least one sebaceous skin tumor associated with internal malignancies. Whether positron emission tomography/computed tomography (PET/CT) is useful for the detection of malignancies in patients with MTS has not been determined. We herein report two cases in which PET/CT was useful for the diagnosis and follow-up of internal malignancies in patients with MTS. Case presentation: In case 1, a 57-year-old woman underwent excision of a sebaceous carcinoma on the left upper eyelid. She underwent follow-up PET/CT once yearly thereafter. Forty-two months after the eyelid surgery, PET/CT showed intense tracer uptake in the right lower abdomen. An ascending colon tumor was identified, and examination of a biopsy specimen showed adenocarcinoma. In case 2, a 77-year-old man presented for evaluation of three continuous papules with telangiectasia on his right cheek. Examination of a skin biopsy specimen of the cheek papule revealed a sebaceous carcinoma. He underwent PET/CT to detect other malignancies. PET/CT showed intense tracer uptake in the sigmoid colon. A sigmoid colon tumor was identified, and examination of a biopsy specimen showed adenocarcinoma. Both patients underwent resection of their tumors, and both were still free of recurrence of the sebaceous and colon carcinomas at the time of this writing. Conclusion: PET/CT is a reliable imaging modality for the detection of internal malignancies and is useful for the diagnosis and follow-up of MTS.
出版者	en Springer
日付	Issued2017-05-23
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/66641
関連	isIdenticalTo DOI https://doi.org/10.1186/s40792-017-0346-7
収録誌情報	PISSN 2198-7793 en Surgical case reports 巻3 開始ページ71
ファイル	fulltext s40792-017-0346-7.pdf 4.61 MB (application/pdf) Issued2017-05-23
コンテンツ更新日時	2023-07-26