Type XVII collagen coordinates proliferation in the interfollicular epidermis

Watanabe Mika; Natsuga Ken; Nishie Wataru; Kobayashi Yasuaki; Donati Giacomo; Suzuki Shotaro; Fujimura Yu; Tsukiyama Tadasuke; Ujiie Hideyuki; Shinkuma Satoru; Nakamura Hideki; Murakami Masamoto; Ozaki Michitaka; Nagayama Masaharu; Watt Fiona M; Shimizu Hiroshi

タイトル	en Type XVII collagen coordinates proliferation in the interfollicular epidermis
作成者	en Watanabe, Mika en Natsuga, Ken NRID 1000070645457 en Nishie, Wataru NRID 1000020443955 en Kobayashi, Yasuaki en Donati, Giacomo en Suzuki, Shotaro en Fujimura, Yu en Tsukiyama, Tadasuke NRID 1000020399819 en Ujiie, Hideyuki NRID 1000060374435 en Shinkuma, Satoru NRID 1000000613788 en Nakamura, Hideki NRID 1000060435956 en Murakami, Masamoto en Ozaki, Michitaka NRID 1000080256510 en Nagayama, Masaharu NRID 1000020314289 en Watt, Fiona M en Shimizu, Hiroshi NRID 1000000146672
アクセス権	open access
権利情報	https://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
主題	NDC 490
内容注記	Abstract en Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wnt signaling. The replenishment of COL17 in the neonatal epidermis of COL17-null mice reverses the proliferative IFE phenotype and the altered Wnt signaling. Physical aging abolishes membranous COL17 in IFE basal cells because of inactive atypical protein kinase C signaling and also induces epidermal hyperproliferation. The overexpression of human COL17 in aged mouse epidermis suppresses IFE hypertrophy. These findings demonstrate that COL17 governs IFE proliferation of neonatal and aged skin in distinct ways. Our study indicates that COL17 could be an important target of anti-aging strategies in the skin.
出版者	en eLife Sciences Publications
日付	Issued2017-07-11
言語	eng
資源タイプ	journal article
出版タイプ	VoR
資源識別子	HDL http://hdl.handle.net/2115/67060
関連	isIdenticalTo DOI https://doi.org/10.7554/eLife.26635
収録誌情報	PISSN 2050-084X en Elife 巻6 開始ページe26635
ファイル	fulltext elife-26635-v1.pdf 6.78 MB (application/pdf) Issued2017-07-11
コンテンツ更新日時	2023-07-26