| タイトル |
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en
Comparative analyses of whole-genome protein sequences from multiple organisms
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| 作成者 |
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| アクセス権 |
open access |
| 権利情報 |
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| 主題 |
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Other
ja
ゲノム
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Other
ja
蛋白質解析
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NDC
460
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| 内容注記 |
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Abstract
en
Phylogenies based on entire genomes are a powerful tool for reconstructing the Tree of Life. Several methods have been proposed, most of which employ an alignment-free strategy. Average sequence similarity methods are different than most other whole-genome methods, because they are based on local alignments. However, previous average similarity methods fail to reconstruct a correct phylogeny when compared against other whole-genome trees. In this study, we developed a novel average sequence similarity method. Our method correctly reconstructs the phylogenetic tree of in silico evolved E. coli proteomes. We applied the method to reconstruct a whole-proteome phylogeny of 1,087 species from all three domains of life, Bacteria, Archaea, and Eucarya. Our tree was automatically reconstructed without any human decisions, such as the selection of organisms. The tree exhibits a concentric circle-like structure, indicating that all the organisms have similar total branch lengths from their common ancestor. Branching patterns of the members of each phylum of Bacteria and Archaea are largely consistent with previous reports. The topologies are largely consistent with those reconstructed by other methods. These results strongly suggest that this approach has sufficient taxonomic resolution and reliability to infer phylogeny, from phylum to strain, of a wide range of organisms.
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| 出版者 |
en
Nature Publishing Group
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
VoR |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/70684
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| 関連 |
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isIdenticalTo
DOI
https://doi.org/10.1038/s41598-018-25090-8
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| 収録誌情報 |
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en
Scientific reports
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巻8
開始ページ6800
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| ファイル |
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| コンテンツ更新日時 |
2023-07-26 |
