タイトル |
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Vocal practice regulates singing activity-dependent genes underlying age-independent vocal learning in songbirds
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作成者 |
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アクセス権 |
open access |
権利情報 |
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主題 |
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Other
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Bird song
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Other
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Birds
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Other
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Neuronal dendrites
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Other
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Learning
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Other
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Syllables
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Other
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Gene regulation
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Other
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Zebra finch
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Other
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Bird genetics
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NDC
480
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内容注記 |
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Abstract
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The development of highly complex vocal skill, like human language and bird songs, is underlain by learning. Vocal learning, even when occurring in adulthood, is thought to largely depend on a sensitive/critical period during postnatal development, and learned vocal patterns emerge gradually as the long-term consequence of vocal practice during this critical period. In this scenario, it is presumed that the effect of vocal practice is thus mainly limited by the intrinsic timing of age-dependent maturation factors that close the critical period and reduce neural plasticity. However, an alternative, as-yet untested hypothesis is that vocal practice itself, independently of age, regulates vocal learning plasticity. Here, we explicitly discriminate between the influences of age and vocal practice using a songbird model system. We prevented zebra finches from singing during the critical period of sensorimotor learning by reversible postural manipulation. This enabled to us to separate lifelong vocal experience from the effects of age. The singing-prevented birds produced juvenile-like immature song and retained sufficient ability to acquire a tutored song even at adulthood when allowed to sing freely. Genome-wide gene expression network analysis revealed that this adult vocal plasticity was accompanied by an intense induction of singing activity-dependent genes, similar to that observed in juvenile birds, rather than of age-dependent genes. The transcriptional changes of activity-dependent genes occurred in the vocal motor robust nucleus of the arcopallium (RA) projection neurons that play a critical role in the production of song phonology. These gene expression changes were accompanied by neuroanatomical changes: dendritic spine pruning in RA projection neurons. These results show that self-motivated practice itself changes the expression dynamics of activity-dependent genes associated with vocal learning plasticity and that this process is not tightly linked to age-dependent maturational factors.
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出版者 |
en
PLOS
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日付 |
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言語 |
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資源タイプ |
journal article |
出版タイプ |
VoR |
資源識別子 |
HDL
http://hdl.handle.net/2115/73008
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関連 |
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isIdenticalTo
DOI
https://doi.org/10.1371/journal.pbio.2006537
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収録誌情報 |
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PLoS biology
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巻16
号9
開始ページe2006537
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ファイル |
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コンテンツ更新日時 |
2023-07-26 |