Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma

Kuwabara Shota; Tsuchikawa Takahiro; Nakamura Toru; Hatanaka Yutaka; Hatanaka Kanako C.; Sasaki Katsunori; Ono Masato; Umemoto Kazufumi; Suzuki Tomohiro; Sato Osamu; Hane Yuma; Nakanishi Yoshitsugu; Asano Toshimichi; Ebihara Yuma; Kurashima Yo; Noji Takehiro; Murakami Soichi; Okamura Keisuke; Shichinohe Toshiaki; Hirano Satoshi

タイトル	en Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma
作成者	en Kuwabara, Shota en Tsuchikawa, Takahiro NRID 1000050507572 en Nakamura, Toru NRID 1000070645796 en Hatanaka, Yutaka NRID 1000030589924 en Hatanaka, Kanako C. en Sasaki, Katsunori NRID 1000060336394 en Ono, Masato en Umemoto, Kazufumi en Suzuki, Tomohiro en Sato, Osamu en Hane, Yuma en Nakanishi, Yoshitsugu NRID 1000040447058 en Asano, Toshimichi NRID 1000010756688 en Ebihara, Yuma NRID 1000050632981 en Kurashima, Yo NRID 1000040374350 en Noji, Takehiro NRID 1000010739296 en Murakami, Soichi NRID 1000080706573 en Okamura, Keisuke NRID 1000090724401 en Shichinohe, Toshiaki NRID 1000070374353 en Hirano, Satoshi NRID 1000050322813
アクセス権	metadata only access
権利情報	http://creativecommons.org/licenses/by/4.0/ en Creative Commons Attribution 4.0 International
主題	Other en chemoradiotherapy Other en immunology Other en neoadjuvant Other en pancreatic cancer Other en tumor microenvironment NDC 490
内容注記	Abstract en The efficacy of preoperative neoadjuvant chemoradiotherapy (NAC) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs (TLO) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. We retrospectively investigated the clinical relevance of TLO by categorizing patients into those who underwent upfront surgery (surgery first [SF]) and those who received NAC. The immunological elements within TLO were analyzed by immunohistochemistry (IHC). In the IHC analysis, the proportions of CD8+ T lymphocytes, PNAd+ high endothelial venules, CD163+ macrophages and Ki-67+ cells within the TLO were higher in the NAC group than in the SF group. In contrast, the proportion of programmed cell death-1+ immunosuppressive lymphocytes within TLO was lower in the NAC group than in the SF group. The NAC group demonstrated favorable prognoses compared with the SF group. In the multivariate analysis, the TLO/tumor ratio was determined as an independent predictive prognostic factor. In conclusion, the administration of preoperative chemoradiotherapy may influence the immunological elements in the tumor microenvironment and result in favorable prognoses in pancreatic ductal adenocarcinoma patients.
出版者	en John Wiley & Sons
日付	Issued2019-06
言語	eng
資源タイプ	journal article
出版タイプ	NA
資源識別子	HDL http://hdl.handle.net/2115/75208
関連	isIdenticalTo DOI https://doi.org/10.1111/cas.14023 PMID 30997706
収録誌情報	PISSN 1347-9032 en Cancer science 巻110 号6 開始ページ1853 終了ページ1862
コンテンツ更新日時	2023-07-26