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Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction
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| アクセス権 |
metadata only access |
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| 内容注記 |
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Abstract
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Antitumor drug development based on the concept of intervening in the antioxidant system of cancer cells has been gaining increased interest. In this study, we propose a promising strategy for cancer treatment using modulation of oxidative stress by suppression of glutathione S-transferases (GSTs), a typical antioxidant enzyme. siRNA which can be applied to the development of nucleic acid drugs, enabling them to eliminate unwanted side effects, increase specificity, and avoid the problem of drug resistance, was employed for GSTP-silencing at the transcriptional level. The silencing of the pi class of GST (GSTP) that displayed the most characteristic expression profile in 13 kinds of cancer cell lines has shown significant impairment in the growth of cancer cells due to oxidative stress caused by excess ROS accumulation. Comparative proteomics between normal cells and GSTP-silenced pancreatic cancer cell PANC-1 suggested that GSTP-silencing facilitated the mitochondria! dysfunction. These findings show promise for the development of strategies toward cancer therapy based on the mechanism that allows genetic silencing of GSTP to promote oxidative stress through mitochondria dysfunction.
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| 出版者 |
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Nature Publishing Group
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| 日付 |
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| 言語 |
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| 資源タイプ |
journal article |
| 出版タイプ |
NA |
| 資源識別子 |
HDL
http://hdl.handle.net/2115/76195
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isIdenticalTo
DOI
https://doi.org/10.1038/s41598-019-51462-9
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PMID
31611630
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| 収録誌情報 |
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en
Scientific reports
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巻9
開始ページ14764
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| コンテンツ更新日時 |
2023-07-26 |
