一覧に戻る

タイトル
  • Mutational analysis of β-arrestin in Japanese patients with coronary spastic angina
作成者
    • Kudo, Natsumi
    • Hanada, Kenji
    • Kawamura, Yosuke
    • Nakata, Masamichi
    • Nozaka, Masashi
    • Kitayama, Kazutaka
    • Miura, Naotake
    • Tanaka, Makoto
    • Osanai, Tomohiro
    • Tomita, Hirofumi
主題
  • Other Coronary spastic angina
  • Other Prinzmetal variant angina
  • Other β-arrestin
  • Other Mutational analysis
  • Other Direct sequencing
内容注記
  • Abstract Coronary spastic angina （CSA） has become increasingly important for clinical practice. β-arrestin regulates a large network of cellular responses including inflammation and muscle contraction. However, little is known about its role in the pathogenesis of CSA. In this study, we performed mutational analysis of β-arrestin1 and β-arrestin2 genes in CSA patients. The study population included 20 CSA patients and 5 control subjects. Mutational analyses of the coding egions of β-arrestins were performed by direct sequencing. In β-arrestin1, single base heterozygous substitution at nucleotide position 176 in exon 5 was detected in 2 of 20 CSA patients, whereas no substitution was detected in control subjects. We subsequently performed an association study involving 50 CSA patients and 50 control subjects. No ifference was found in the incidence of the mutation between the two groups （p=0.44）. In β-arrestin2, single base substitution at nucleotide position 61 in exon 11 was detected. This substitution was homozygous in 13 and heterozygous in 7 of 20 CSA patients, whereas all homozygous in 5 control subjects. These substitutions were well-annotated SNPs rs877711 and rs1045280, respectively） and did not cause amino acid replacement. No significant substitution of the oding regions of β-arrestins was detected in Japanese CSA patients.
出版者 弘前大学大学院医学研究科
日付
    Issued2020-03-02
言語
  • eng
資源タイプ journal article
出版タイプ VoR
資源識別子 HDL http://hdl.handle.net/10129/00006964 , URI https://hirosaki.repo.nii.ac.jp/records/5897
収録誌情報
    • NCID AN00211444
    • ISSN 0439-1721
      • 弘前医学
      • 巻70 号2-4 開始ページ148 終了ページ155
ファイル
コンテンツ更新日時 2023-07-07