Title |
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Useful Measurement of Glucose Variability by Flash Glucose Monitoring (FGM) with the Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
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Rights |
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© 2020 Ebe K, Bando H, Muneta T, Bando M, Yonei Y. This is an open-access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Subject |
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Other
Low Carbohydrate Diet
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Other
Continuous Glucose Monitoring
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Other
FreeStyle Libre Pro
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Other
Flash Glucose Monitoring
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Other
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
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Other
Japan LCD Promotion Association (JLCDPA)
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Description |
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Other
Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research.
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Asploro
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journal article |
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Identifier |
URI
http://repo.lib.tokushima-u.ac.jp/114793
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DOI
https://doi.org/10.36502/2020/droa.6154
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Journal |
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Diabetes Research : Open Access
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Volume Number2
Issue NumberS1
Page Start1
Page End8
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Oaidate |
2023-06-26 |