• The Uteroglobin Gene G38A Polymorphism Is Not Associated with Kawasaki Disease

Nakashima, Kazuhisa

Ikeda, Kazuyuki

Nishimura, Shinji

Shibata, Yoshisada

Motomura, Hideki

Ohno, Takuro

Zaitsu, Masafumi

Hara, Toshiro

Hamasaki, Yuhei

Moriuchi, Hiroyuki

  • Other Vasculitis
  • Other Coronary artery lesion
  • This study analyzed the genomic DNA extracted from 170 patients with Kawasaki disease as well as their clinical and laboratory parametersto determine whether uteroglobin gene polymorphism, which may be associated with the morbidity rate and severity of IgA nephropathy, is involvedin the pathogenesis of Kawasaki disease, which is another type of vasculitic syndrome in childhood. The uteroglobin genotype at position38 was determined by Sau96I digestion of PCR products. The uteroglobin genotype and allele frequency in Kawasaki disease patientswere compared with those of published control data reported by three independent studies on Japanese individuals. The clinical parametersinvestigated were age at onset, gender, duration of fever, white blood cell count, C-reactive protein, aspartate aminotransferase, alanineaminotransferase and total protein. No significant difference associated with the uteroglobin genotype was observed in the clinical parameters.The genotypic and allele frequencies at position 38 of the uteroglobin gene did not differ significantly in the three studies of Japanese healthycontrols and the present study. The logistic regression analysis demonstrated that no clinical parameter was associated with the progressionto coronary artery lesions except for the duration of fever (odds ratio = 1.7; 95% confidential interval = 1.42-2.05). In conclusion, the presentstudy failed to prove an association of uteroglobin gene polymorphism with the morbidity rate or the severity of Kawasaki disease, but suggestedthe existence of a factor contributing to the onset of Kawasaki disease and progression to coronary artery lesions in Kawasaki diseasepatients.
  • identifier:Acta medica Nagasakiensia, 54(3), pp.53-58 ; 2010
PublisherNagasaki University School of Medicine
Date Issued 2010-03
NIItypedepartmental bulletin paper
Identifier URI
    • ISSN 0001-6055
    • Acta medica Nagasakiensia
    54(3), 53-58