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Title
  • Protective effects of intranasal vaccination with plasmid encoding pseudorabies virus glycoprotein B in mice
Creator

TAKADA, Ayato

OKAZAKI, Katsunori

KIDA, Hiroshi

Subject
  • Other DNA vaccine
  • Other intranasal vaccination
  • Other mucosal immunity
  • Other pseudorabies virus
  • NDC 649
Description
Other
  • Intranasal administration of plasmid DNA encoding glycoprotein B of pseudorabies virus into mice induced both serum and secretory antibody responses. These mice resisted intranasal challenge with lethal dose of the virus, but did not intraperitoneal challenge. On the other hand, intramuscular injection of the plasmid induced less secretory and higher serum antibody responses than those of intranasally vaccinated mice. None of them was protected from virus challenge. The present results suggest that administration of plasmid DNA encoding glycoprotein B by respiratory mucosal route generates local secretory antibodies which serve to protect animals from pseudorabies virus infection.
PublisherThe Graduate School of Veterinary Medicine
Date Issued 1999-08-31
Languageeng
NIItypedepartmental bulletin paper
VersiontypeVoR
Identifier URI http://hdl.handle.net/2115/2726 , DOI https://doi.org/10.14943/jjvr.47.1-2.25
ID

JaLC10.14943/jjvr.47.1-2.25

Journal
    • NCID AA0069128X
    • ISSN 0047-1917
    • Japanese Journal of Veterinary Research
    47(1-2), 25-33
File
Oaidate2019-04-25T00:52:06Z