Title |
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Heredity in Multiple System Atrophy
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Creator |
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Accessrights |
open access |
Subject |
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Other
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Multiple System Atrophy
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Other
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Family History
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Other
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Multigenic Aetiology
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Other
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Spinocerebellar Ataxia
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Other
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Parkinsonism
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Other
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Neurodegenerative Disorders
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NDC
493.73
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Description |
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Abstract
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We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary spinocerebellar ataxia with a similar clinical phenotype to MSA. The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background.
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Publisher |
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Elsevier B.V.
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Date |
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Language |
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Resource Type |
journal article |
Version Type |
AM |
Identifier |
HDL
http://hdl.handle.net/2115/4859
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Relation |
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URI
http://www.sciencedirect.com/science/journal/0022510X
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isVersionOf
DOI
https://doi.org/10.1016/j.jns.2005.09.003
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PMID
16307759
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Journal |
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Journal of the Neurological Sciences
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Volume Number240
Issue Number1-2
Page Start107
Page End110
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File |
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Oaidate |
2023-07-26 |