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Title
  • en Heredity in Multiple System Atrophy
Creator
    • en Soma, Hiroyuki
    • en Takei, Asako
    • en Fujiki, Naoto
    • en Yanagihara, Tetsuro
Accessrights open access
Subject
  • Other en Multiple System Atrophy
  • Other en Family History
  • Other en Multigenic Aetiology
  • Other en Spinocerebellar Ataxia
  • Other en Parkinsonism
  • Other en Neurodegenerative Disorders
  • NDC 493.73
Description
  • Abstract en We investigated the family histories of 157 Japanese patients with probable or possible multiple system atrophy (MSA). A family history of neurodegenerative disorders was only detected in three MSA patients (1.9%). We evaluated these patients by careful neurological examination, neuroimaging studies, and genetic studies to exclude hereditary spinocerebellar ataxia with a similar clinical phenotype to MSA. The results indicated that one of them had a family history of MSA. Although the familial presence of neurodegenerative disorders is rare in MSA patients, the existence of such cases suggests that MSA may have a genetic background.
Publisher en Elsevier B.V.
Date
    Issued2006-01-15
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/4859
Relation
  • URI http://www.sciencedirect.com/science/journal/0022510X
  • isVersionOf DOI https://doi.org/10.1016/j.jns.2005.09.003
  • PMID 16307759
Journal
    • PISSN 0022-510X
      • en Journal of the Neurological Sciences
      • Volume Number240 Issue Number1-2 Page Start107 Page End110
File
Oaidate 2023-07-26