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Title
  • en Immunolocalization of cyclin D1 in the developing lens of c-maf -/- mice
Creator
Accessrights open access
Subject
  • Other en C-maf
  • Other en Cyclin D1
  • Other en Lens
  • Other en Immunohistochemistry
  • NDC 496.1
Description
  • Abstract en The maf gene encodes a transcription factor protein containing a typical basic/leucine zipper domain structure, a motif for protein dimerization and DNA binding. It has been demonstrated that maf family genes have important roles in embryonic development and cellular differentiation. In this study, localization of cyclin D1, one of the cell cycle-related molecules, was examined immunohistochemically in developing lens cells of c-maf knockout (-/-) mice. At embryonic day 14 in wild-type mice, lens cells consisted of round epithelial cells in a single layer and regularly arranged elongated lens cells, indicating primary lens fiber cells. Cyclin D1-positive nuclei were observed in the lens epithelial cells, whereas cyclin D1 was not detected in the primary lens fiber cells. In c-maf -/- mice, a variety of round epithelial cells were located in the anterior and posterior lens. Many cyclin D1-positive nuclei were observed in lens epithelial cells as well as posterior lens cells. These results are consistent with c-maf playing a role in the regulation of cyclin D1 in developing lens cells.
Publisher en Elsevier
Date
    Issued2006-02-20
Language
  • eng
Resource Type journal article
Version Type AM
Identifier HDL http://hdl.handle.net/2115/5980
Relation
  • URI http://www.sciencedirect.com/science/journal/00651281
  • isVersionOf DOI https://doi.org/10.1016/j.acthis.2005.10.002
  • PMID 16325892
Journal
    • PISSN 0065-1281
      • en Acta Histochemica
      • Volume Number107 Issue Number6 Page Start469 Page End472
File
    • fulltext AH107_6.pdf
    • 84.02 KB (application/pdf)
      • Issued2006-02-20
Oaidate 2023-07-26